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Boosting plant food polyphenol concentration by saline eustress as supplement strategies for the prevention of metabolic syndrome: an example of randomized interventional trial in the adult population.
Ferrantelli, Vincenzo; Vasto, Sonya; Alongi, Angelina; Sabatino, Leo; Baldassano, Davide; Caldarella, Rosalia; Gagliano, Rosaria; Di Rosa, Luigi; Consentino, Beppe Benedetto; Vultaggio, Lorena; Baldassano, Sara.
Afiliación
  • Ferrantelli V; Experimental Zooprophylactic Institute of Sicily, Palermo, Italy.
  • Vasto S; Euro-Mediterranean Institutes of Science and Technology (IEMEST), Palermo, Italy.
  • Alongi A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
  • Sabatino L; Experimental Zooprophylactic Institute of Sicily, Palermo, Italy.
  • Baldassano D; Dipartimento Scienze Agrarie, Alimentari e Forestali, University of Palermo, Palermo, Italy.
  • Caldarella R; Department of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine (ProMISE) G. D'Alessandro, University of Palermo, Palermo, Italy.
  • Gagliano R; Department of Laboratory Medicine, "P. Giaccone" University Hospital, Palermo, Italy.
  • Di Rosa L; Experimental Zooprophylactic Institute of Sicily, Palermo, Italy.
  • Consentino BB; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy.
  • Vultaggio L; Dipartimento Scienze Agrarie, Alimentari e Forestali, University of Palermo, Palermo, Italy.
  • Baldassano S; Dipartimento Scienze Agrarie, Alimentari e Forestali, University of Palermo, Palermo, Italy.
Front Nutr ; 10: 1288064, 2023.
Article en En | MEDLINE | ID: mdl-38196756
ABSTRACT

Introduction:

Phenolic compounds in lettuce can increase by the application of positive stress (eustress) such as moderate saline stress. Phenolic compounds possess antioxidant capacity that is a key factor in the detoxification of excess reactive oxygen species. A double-blinded randomized interventional and placebo- controlled study design was carried out to compare the effect of daily dietary eustress lettuce ingestion in hepatic, lipid, bone, glucose, and iron metabolism.

Methods:

Forty-two healthy volunteers, 19 female and 23 male participants, were divided into two groups. Participants were randomized into a polyphenol-enriched treatment (PET) arm or control arm. Each arm consumed 100 g/day of control or eustress (polyphenols enriched treatment = PET) lettuce for 12 days. Primary study outcomes were serological analysis for assessing hepatic, lipid, bone, iron, and glucose markers at baseline and after 12 days. Secondary outcomes assessed body composition.

Results:

Salinity stress reduced plant yield but increased caffeic acid (+467%), chlorogenic acid (+320%), quercetin (+538%), and rutin (+1,095%) concentrations. The intake of PET lettuce reduced PTH, low-density lipoprotein (LDL), cholesterol, alanine transaminase (ALT), and aspartate transaminase (AST) enzyme levels and increased vitamin D and phosphate levels, while iron and glucose metabolism were unaffected.

Discussion:

Supplementation with eustress lettuce by increasing polyphenols concentration ameliorates hepatic, lipid, and bone homeostasis. Body composition was not affected. Clinical trial registration https//classic.clinicaltrials.gov/ct2/show/NCT06002672, identifier NCT06002672.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Front Nutr Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Front Nutr Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza