Your browser doesn't support javascript.
loading
Lactate administration improves laboratory parameters in murine models of iron overload.
Liu, Wei; Wu, Yue; Wei, Huaiqing; Ma, Juan; Feng, Wenya; Yang, Qiuyuan; Zhang, Shuping; Ganz, Tomas; Liu, Sijin.
Afiliación
  • Liu W; Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
  • Wu Y; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  • Wei H; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  • Ma J; University of Chinese Academy of Sciences, Beijing, China.
  • Feng W; Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
  • Yang Q; Biomedical Sciences College and Shandong Medicinal Biotechnology Centre, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
  • Zhang S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
  • Ganz T; University of Chinese Academy of Sciences, Beijing, China.
  • Liu S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Blood ; 143(11): 1045-1049, 2024 03 14.
Article en En | MEDLINE | ID: mdl-38194678
ABSTRACT
ABSTRACT Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in ß-thalassemic mice.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Talasemia beta / Sobrecarga de Hierro Límite: Animals Idioma: En Revista: Blood Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Talasemia beta / Sobrecarga de Hierro Límite: Animals Idioma: En Revista: Blood Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos