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Medication Non-adherence in Depression: A Systematic Review and Metanalysis.
Lassen, Roseane Halkjaer; Gonçalves, Walter; Gherman, Bruno; Coutinho, Evandro; Nardi, Antonio E; Peres, Maria Angélica; Appolinario, José Carlos.
Afiliación
  • Lassen RH; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil.
  • Gonçalves W; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil.
  • Gherman B; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil.
  • Coutinho E; Department of Epidemiology, Social Medicine Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Nardi AE; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil.
  • Peres MA; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil. Nursing School Anna Nery, Federal University of Rio de Janeiro (EEAN-UFRJ), RJ, Brazil.
  • Appolinario JC; Treatment-Resistant Depression Group, Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), RJ, Brazil.
Trends Psychiatry Psychother ; 2024 Jan 09.
Article en En | MEDLINE | ID: mdl-38194498
ABSTRACT

OBJECTIVE:

Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of non-adherence to antidepressant in MDD.

METHODS:

A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and the protocol was registered in PROSPERO under the number CRD42021199987. Studies assessing medication adherence in MDD were searched in PubMed/Medline, Embase, CINAHL (The Cumulative Index to Nursing and Allied Health Literature) and PsycINFO. The data extraction was performed by two independents authors. Meta-analysis used random effects model and performed a subgroup analysis.

RESULTS:

From the articles retrieved, eleven studies were considered eligible for the final analysis. Most of them assessed non-adherence by self-report scales, followed by Pharmacy Dispensation Records, Monitoring Events Medication System (MEMS) and blood tests. The pooled proportion of non-adherence was 42% (95% IC 30%-54%), but heterogeneity was very large (I2=99%).

CONCLUSION:

Data from the selected studies suggests that a high number of individuals with MDD do not adequately take their medication as prescribed. The high heterogenicity of measures used for the assessment of adherence may have impacted the great variability of the results. The results suggest it is necessary that health care professionals should address this issue in order to achieve a better treatment outcome in major depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Trends Psychiatry Psychother Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Trends Psychiatry Psychother Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil