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mosGILT controls innate immunity and germ cell development in Anopheles gambiae.
Arora, Gunjan; Tang, Xiaotian; Cui, Yingjun; Yang, Jing; Chuang, Yu-Min; Joshi, Jayadev; Sajid, Andaleeb; Dong, Yuemei; Cresswell, Peter; Dimopoulos, George; Fikrig, Erol.
Afiliación
  • Arora G; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA. arorag1983@gmail.com.
  • Tang X; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
  • Cui Y; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
  • Yang J; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
  • Chuang YM; Current Affiliation: Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, China.
  • Joshi J; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
  • Sajid A; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, 44195, USA.
  • Dong Y; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 06520, USA.
  • Cresswell P; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 21205, USA.
  • Dimopoulos G; Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, 06510, USA.
  • Fikrig E; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 21205, USA.
BMC Genomics ; 25(1): 42, 2024 Jan 09.
Article en En | MEDLINE | ID: mdl-38191283
ABSTRACT
Gene-edited mosquitoes lacking a gamma-interferon-inducible lysosomal thiol reductase-like protein, namely (mosGILTnull) have lower Plasmodium infection, which is linked to impaired ovarian development and immune activation. The transcriptome of mosGILTnull Anopheles gambiae was therefore compared to wild type (WT) mosquitoes by RNA-sequencing to delineate mosGILT-dependent pathways. Compared to WT mosquitoes, mosGILTnull A. gambiae demonstrated altered expression of genes related to oogenesis, 20-hydroxyecdysone synthesis, as well as immune-related genes. Serendipitously, the zero population growth gene, zpg, an essential regulator of germ cell development was found to be one of the most downregulated genes in mosGILTnull mosquitoes. These results provide a crucial missing link between two previous studies on the role of zpg and mosGILT in ovarian development. This study further demonstrates that mosGILT has the potential to serve as a target for the biological control of mosquito vectors and to influence the Plasmodium life cycle within the vector.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anopheles Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anopheles Límite: Animals Idioma: En Revista: BMC Genomics Asunto de la revista: GENETICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido