Preparation of Spirocyclic Vinylic Carbonates from Allylic Alcohols.

Topp, Christopher; Metzler, Jan M; Dressler, Friedemann; Niedek, Dominik; Schuler, Sören M M; Schreiner, Peter R

Topp, Christopher; Metzler, Jan M; Dressler, Friedemann; Niedek, Dominik; Schuler, Sören M M; Schreiner, Peter R.

Afiliación

Topp C; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Metzler JM; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Dressler F; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Niedek D; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Schuler SMM; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Schreiner PR; Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.

Org Lett ; 26(3): 577-580, 2024 Jan 26.

Article en En | MEDLINE | ID: mdl-38190695

ABSTRACT

ABSTRACT

We present the synthesis of exo- and endo-spirovinylethylene carbonates, starting from various cyclic allylic alcohols. This one-pot cascade reaction to the spirocyclic scaffold was optimized using a design of experiments approach. The introduction of spirovinylethylene carbonates broadens the scope of using these in catalytic applications and provides an easy synthetic entry into spirocyclic scaffolds of various ring sizes.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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