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Anti-obesity and metabolic benefits of metformin: Comparison of different delivery routes.
Abbasi, Mehrnaz; Fan, Zhaoyang; Dawson, John A; Wang, Shu.
Afiliación
  • Abbasi M; Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas 79409, USA.
  • Fan Z; College of Human Sciences, Auburn University, Auburn, AL, 36830, USA.
  • Dawson JA; Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas 79409, USA.
  • Wang S; School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona 85281, USA.
J Drug Deliv Sci Technol ; 912024 Jan.
Article en En | MEDLINE | ID: mdl-38188941
ABSTRACT
Obesity is a severe public health problem. Healthy lifestyle interventions are commonly recommended for fighting obesity. But they are hard to follow and have low efficacy. Pharmacotherapy and surgery are of high efficacy but are beset with side effects. Browning subcutaneous white adipose tissue (WAT) is a practical and efficient approach for combating obesity. Metformin, a commonly used FDA-approved antidiabetic drug, is potent to induce browning of WAT through phosphorylation and activation of AMP-activated protein kinase. However, oral administration of metformin has low oral bioavailability, fast renal clearance, and low target specificity that limit metformin's application in browning WAT. Local and transdermal delivery of metformin directly to subcutaneous WAT using injection or microneedle (MN) in combination with iontophoresis (INT) may solve these problems. In this paper, we administered metformin to C57BL/6J obese mice using the following three routes transdermal delivery (MN and INT), local injection into inguinal WAT (IgWAT, a type of subcutaneous WAT in mice), and oral gavage. The anti-obesity and metabolic effects of metformin via these delivery routes were determined and compared. As compared to local IgWAT injection and oral gavage delivery, transdermal delivery of metformin using MN and INT resulted in 9% lower body weight and 7% decrease in body fat% accompanied by improved energy metabolism and decreased inflammation through browning IgWAT in obese C57BL/6J mice. Transdermal delivery of metformin using MN and INT is an effective approach in browning subcutaneous WAT for combating obesity and improving metabolic health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Drug Deliv Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Drug Deliv Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia