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TonEBP expression is essential in the IL-1ß-induced migration and invasion of human A549 lung cancer cells.
Song, Hee Ju; Kim, Taehee; Choi, Han Na; Kim, Soo Jin; Lee, Sang DO.
Afiliación
  • Song HJ; Department of Physiology, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.
  • Kim T; Department of Physiology, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.
  • Choi HN; Department of Physiology, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.
  • Kim SJ; Department of Physiology, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.
  • Lee SD; Department of Physiology, School of Medicine, Chungnam National University, Daejeon, 35015, Korea.
Oncol Res ; 32(1): 151-161, 2023.
Article en En | MEDLINE | ID: mdl-38188678
ABSTRACT
Lung cancer has the highest mortality rate among all cancers, in part because it readily metastasizes. The tumor microenvironment, comprising blood vessels, fibroblasts, immune cells, and macrophages [including tumor-associated macrophages (TAMs)], is closely related to cancer cell growth, migration, and invasion. TAMs secrete several cytokines, including interleukin (IL)-1ß, which participate in cancer migration and invasion. p21-activated kinase 1 (PAK1), an important signaling molecule, induces cell migration and invasion in several carcinomas. Tonicity-responsive enhancer-binding protein (TonEBP) is also known to participate in cancer cell growth, migration, and invasion. However, the mechanisms by which it increases lung cancer migration remain unclear. Therefore, in this study, we aimed to elucidate the mechanisms by which IL-1ß and TonEBP affect lung cancer cell migration and invasion. We found that A549 cocultured-MΦ-secreted IL-1ß induced A549 cell migration and invasion via the PAK1 pathway. TonEBP deficiency reduced A549 cell migration and invasion and increased responsiveness to IL-1ß-induced migration and invasion. PAK1 phosphorylation, which was promoted by IL-1ß, was reduced when TonEBP was depleted. These results suggest that TonEBP plays an important role in IL-1ß induction and invasiveness of A549 cells via the PAK1 pathway. These findings could be valuable in identifying potential targets for lung cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción NFATC / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Oncol Res Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción NFATC / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Oncol Res Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos