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Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector.
Harary, Tamar; Nagli, Michael; Suleymanov, Nathan; Goykhman, Ilya; Rosenthal, Amir.
Afiliación
  • Harary T; Technion - Israel Institute of Technology, The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Haifa, Israel.
  • Nagli M; Technion - Israel Institute of Technology, The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Haifa, Israel.
  • Suleymanov N; Technion - Israel Institute of Technology, The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Haifa, Israel.
  • Goykhman I; Technion - Israel Institute of Technology, The Andrew and Erna Viterbi Faculty of Electrical and Computer Engineering, Haifa, Israel.
  • Rosenthal A; The Hebrew University of Jerusalem, Institute of Applied Physics and Institute of Chemistry, Faculty of Science, Jerusalem, Israel.
J Biomed Opt ; 29(Suppl 1): S11511, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38187934
ABSTRACT

Significance:

Optical-resolution optoacoustic microscopy (OR-OAM) enables label-free imaging of the microvasculature by using optical pulse excitation and acoustic detection, commonly performed by a focused optical beam and an ultrasound transducer. One of the main challenges of OR-OAM is the need to combine the excitation and detection in a coaxial configuration, often leading to a bulky setup that requires physically scanning the ultrasound transducer to achieve a large field of view.

Aim:

The aim of this work is to develop an OR-OAM configuration that does not require physically scanning the ultrasound transducer or the acoustic beam path.

Approach:

Our OR-OAM system is based on a non-coaxial configuration in which the detection is performed by a silicon-photonics acoustic detector (SPADE) with a semi-isotropic sensitivity. The system is demonstrated in both epi- and trans-illumination configurations, where in both configurations SPADE remains stationary during the imaging procedure and only the optical excitation beam is scanned.

Results:

The system is showcased for imaging resolution targets and for the in vivo visualization of the microvasculature in a mouse ear. Optoacoustic imaging with focal spots down to 1.3 µm, lateral resolution of 4 µm, and a field of view higher than 4 mm in both lateral dimensions were demonstrated.

Conclusions:

We showcase a new OR-OAM design, compatible with epi-illumination configuration. This setup enables relatively large fields of view without scanning the acoustic detector or acoustic beam path. Furthermore, it offers the potential for high-speed imaging within compact, miniature probe and could potentially facilitate the clinical translation of OR-OAM technology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Microscopía Límite: Animals Idioma: En Revista: J Biomed Opt Asunto de la revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Microscopía Límite: Animals Idioma: En Revista: J Biomed Opt Asunto de la revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos