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Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala.
Li, Zhenlong; Lee, Chau-Shoun; Chen, Si; He, Benyu; Chen, Xinya; Peng, Hsien-Yu; Lin, Tzer-Bin; Hsieh, Ming-Chun; Lai, Cheng-Yuan; Chou, Dylan.
Afiliación
  • Li Z; School of Basic Medical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
  • Lee CS; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
  • Chen S; Department of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan.
  • He B; School of Basic Medical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
  • Chen X; School of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
  • Peng HY; School of Basic Medical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
  • Lin TB; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
  • Hsieh MC; Institute of Biomedical Sciences, MacKay Medical College, New Taipei, Taiwan.
  • Lai CY; Institute of New Drug Development, College of Medicine, China Medical University, Taichung, Taiwan.
  • Chou D; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Neurobiol Stress ; 28: 100600, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38187456
ABSTRACT
Light is an underappreciated mood manipulator. People are often exposed to electronic equipment, which results in nocturnal blue light exposure in modern society. Light pollution drastically shortens the night phase of the circadian rhythm. Preclinical and clinical studies have reported that nocturnal light exposure can influence mood, such as depressive-like phenotypes. However, the effects of blue light at night (BLAN) on other moods and how it alters mood remain unclear. Here, we explored the impact of BLAN on stress-provoked aggression in male Sprague‒Dawley rats, focusing on its influence on basolateral amygdala (BLA) activity. Resident-intruder tests, extracellular electrophysiological recordings, and enzyme-linked immunosorbent assays were performed. The results indicated that BLAN produces stress-induced heightened aggressive and anxiety-like phenotypes. Moreover, BLAN not only potentiates long-term potentiation and long-term depression in the BLA but also results in stress-induced elevation of brain-derived neurotrophic factor (BDNF), mature BDNF, and phosphorylation of tyrosine receptor kinase B expression in the BLA. Intra-BLA microinfusion of BDNF RNAi, BDNF neutralizing antibody, K252a, and rapamycin blocked stress-induced heightened aggressive behavior in BLAN rats. In addition, intra-BLA application of BDNF and 7,8-DHF caused stress-induced heightened aggressive behavior in naïve rats. Collectively, these results suggest that BLAN results in stress-evoked heightened aggressive phenotypes, which may work by enhancing BLA BDNF signaling and synaptic plasticity. This study reveals that nocturnal blue light exposure may have an impact on stress-provoked aggression. Moreover, this study provides novel insights into the BLA BDNF-dependent mechanism underlying the impact of the BLAN on mood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurobiol Stress Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neurobiol Stress Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos