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Multiple sclerosis and hypogonadism: is there a relationship?
Hammad, Muhammed A M; Rush, Adriana; Loeb, Charles A; Banton, Jasmin; Abou Chawareb, Elia; Khanmammadova, Narmina; Gevorkyan, Rafael R; Barham, David W; Yafi, Faysal A; Jenkins, Lawrence C.
Afiliación
  • Hammad MAM; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Rush A; School of Medicine Greenville, University of South Carolina, Greenville, SC 29605, United States.
  • Loeb CA; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Banton J; College of Osteopathic Medicine, New York Institute of Technology, Jonesboro, Arkansas, NY 11545, United States.
  • Abou Chawareb E; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Khanmammadova N; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Gevorkyan RR; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Barham DW; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Yafi FA; Department of Urology, University of California, Irvine, CA 92868, United States.
  • Jenkins LC; Department of Urology, University of California, Irvine, CA 92868, United States.
Sex Med Rev ; 12(2): 178-182, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38185910
ABSTRACT

INTRODUCTION:

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system and is widely recognized as a disease primarily affecting women. The relationship between MS and hypogonadism is complex and not fully understood, with recent evidence showing that hypogonadism may have a significant impact on the quality of life and disease progression of patients with MS.

OBJECTIVES:

This review aims to provide an overview of the current knowledge regarding the relationship between MS and hypogonadism, including the mechanisms underlying this relationship; the effects of hypogonadism on patients with MS; and the potential benefits and drawbacks of testosterone replacement therapy for patients with MS and hypogonadism.

METHODS:

This scientific review analyzed 19 articles that investigated the potential relationship among MS, testosterone levels, and hypogonadism. The articles were published between November 2008 and March 2022 and were identified through a comprehensive search of the PubMed database. The search terms used included "multiple sclerosis," "testosterone," "hypogonadism," and "MS and testosterone levels."

RESULTS:

Of the 19 articles reviewed, 11 described a positive correlation between low testosterone levels and dysfunction within the hypothalamic-pituitary-gonadal axis in individuals with MS. These findings suggest that low testosterone levels may contribute to dysfunction within the hypothalamus-pituitary-gonadal axis, which plays a crucial role in regulating testosterone production. The results also showed a relationship between sexual dysfunction and low testosterone levels, as well as a positive correlative relationship between these factors.

CONCLUSION:

The reviewed articles indicate a complex relationship among MS, testosterone levels, and the hypothalamic-pituitary-gonadal axis, with low testosterone levels potentially contributing to dysfunction in this axis and to sexual dysfunction. Further research is needed to better understand the effects of testosterone therapy on MS and sexual dysfunction in patients with MS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Hipogonadismo / Esclerosis Múltiple Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Female / Humans / Male Idioma: En Revista: Sex Med Rev Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Hipogonadismo / Esclerosis Múltiple Tipo de estudio: Prognostic_studies Aspecto: Patient_preference Límite: Female / Humans / Male Idioma: En Revista: Sex Med Rev Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos