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The death rate of COVID-19 infection in different SARS-CoV-2 variants was related to C-reactive protein gene polymorphisms.
Sadeghi Mofrad, Sahar; Boozarjomehri Amnieh, Shayan; Pakzad, Mohammad Reza; Zardadi, Mina; Ghazanfari Jajin, Morteza; Anvari, Enayat; Moghaddam, Sina; Fateh, Abolfazl.
Afiliación
  • Sadeghi Mofrad S; Department of Microbiology, Islamic Azad University of Central Tehran Branch, Tehran, Iran.
  • Boozarjomehri Amnieh S; Faculty of Veterinary Medicine, Tabriz Medical Science Branch, Islamic Azad University, Tabriz, Iran.
  • Pakzad MR; Faculty of Veterinary Medicine, Tabriz Medical Science Branch, Islamic Azad University, Tabriz, Iran.
  • Zardadi M; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
  • Ghazanfari Jajin M; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
  • Anvari E; Clinical Research Development Unit, Shahid Mostafa Khomeini Hospital, Ilam University of Medical Science, Ilam, Iran.
  • Moghaddam S; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
  • Fateh A; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. afateh2@gmail.com.
Sci Rep ; 14(1): 703, 2024 01 06.
Article en En | MEDLINE | ID: mdl-38184750
ABSTRACT
The serum level of C-reactive protein (CRP) is a significant independent risk factor for Coronavirus disease 2019 (COVID-19). A link was found between serum CRP and genetic diversity within the CRP gene in earlier research. This study examined whether CRP rs1205 and rs1800947 polymorphisms were associated with COVID-19 mortality among various severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) variants. We genotyped CRP rs1205 and rs1800947 polymorphisms in 2023 deceased and 2307 recovered patients using the polymerase chain reaction-restriction fragment length polymorphism method. There was a significant difference between the recovered and the deceased patients in terms of the minor allele frequency of CRP rs1205 T and rs1800947 G. In all three variants, COVID-19 mortality rates were associated with CRP rs1800947 GG genotype. Furthermore, CRP rs1205 CC and rs1800947 GG genotypes showed higher CRP levels. It was found that the G-T haplotype was prevalent in all SARS-CoV-2 variants. The C-C and C-T haplotypes were statistically significant in Delta and Omicron BA.5 variants, respectively. In conclusion, polymorphisms within the CRP gene may relate to serum CRP levels and mortality among COVID-19 patients. In order to verify the utility of CRP polymorphism correlation in predicting COVID-19 mortality, a replication of these results is needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido