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Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma.
Liu, Zhiwei; Luo, Yang; Kirimunda, Samuel; Verboom, Murielle; Onabajo, Olusegun O; Gouveia, Mateus H; Ogwang, Martin D; Kerchan, Patrick; Reynolds, Steven J; Tenge, Constance N; Were, Pamela A; Kuremu, Robert T; Wekesa, Walter N; Masalu, Nestory; Kawira, Esther; Kinyera, Tobias; Otim, Isaac; Legason, Ismail D; Nabalende, Hadijah; Dhudha, Herry; Ayers, Leona W; Bhatia, Kishor; Goedert, James J; Cole, Nathan; Luo, Wen; Liu, Jia; Manning, Michelle; Hicks, Belynda; Prokunina-Olsson, Ludmila; Chagaluka, George; Johnston, W Thomas; Mutalima, Nora; Borgstein, Eric; Liomba, George N; Kamiza, Steve; Mkandawire, Nyengo; Mitambo, Collins; Molyneux, Elizabeth M; Newton, Robert; Hsing, Ann W; Mensah, James E; Adjei, Anthony A; Hutchinson, Amy; Carrington, Mary; Yeager, Meredith; Blasczyk, Rainer; Chanock, Stephen J; Raychaudhuri, Soumya; Mbulaiteye, Sam M.
Afiliación
  • Liu Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
  • Luo Y; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
  • Kirimunda S; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Verboom M; Division of Rheumatology, Immunology, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Onabajo OO; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Gouveia MH; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Ogwang MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kerchan P; College of Health Sciences, Makerere University, Kampala, Uganda.
  • Reynolds SJ; Institute of Transfusion Medicine and Transplant Engineering, Hanover, Germany.
  • Tenge CN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
  • Were PA; Center for Research on Genomics & Global Health, NHGRI, National Institutes of Health, Bethesda, MD, USA.
  • Kuremu RT; St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Wekesa WN; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Masalu N; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Kawira E; Kuluva Hospital, Arua, Uganda.
  • Kinyera T; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Otim I; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Legason ID; Moi University College of Health Sciences, Eldoret, Kenya.
  • Nabalende H; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Dhudha H; Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.
  • Ayers LW; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Bhatia K; Moi University College of Health Sciences, Eldoret, Kenya.
  • Goedert JJ; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Cole N; Moi University College of Health Sciences, Eldoret, Kenya.
  • Luo W; Bugando Medical Center, Mwanza, Tanzania.
  • Liu J; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Manning M; Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
  • Hicks B; St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Prokunina-Olsson L; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Chagaluka G; St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Johnston WT; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Mutalima N; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Borgstein E; Kuluva Hospital, Arua, Uganda.
  • Liomba GN; St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Kamiza S; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Mkandawire N; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Mitambo C; Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
  • Molyneux EM; Department of Pathology, The Ohio State University, Columbus, OH, USA.
  • Newton R; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
  • Hsing AW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
  • Mensah JE; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Adjei AA; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Hutchinson A; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Carrington M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Yeager M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Blasczyk R; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
  • Chanock SJ; Departments of Pediatrics and Surgery, Kamuzu University of Health Sciences (formerly College of Medicine), University of Malawi, Blantyre, Malawi.
  • Raychaudhuri S; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
  • Mbulaiteye SM; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
Commun Biol ; 7(1): 41, 2024 01 05.
Article en En | MEDLINE | ID: mdl-38182727
ABSTRACT
Burkitt lymphoma (BL) is responsible for many childhood cancers in sub-Saharan Africa, where it is linked to recurrent or chronic infection by Epstein-Barr virus or Plasmodium falciparum. However, whether human leukocyte antigen (HLA) polymorphisms, which regulate immune response, are associated with BL has not been well investigated, which limits our understanding of BL etiology. Here we investigate this association among 4,645 children aged 0-15 years, 800 with BL, enrolled in Uganda, Tanzania, Kenya, and Malawi. HLA alleles are imputed with accuracy >90% for HLA class I and 85-89% for class II alleles. BL risk is elevated with HLA-DQA1*0401 (adjusted odds ratio [OR] = 1.61, 95% confidence interval [CI] = 1.32-1.97, P = 3.71 × 10-6), with rs2040406(G) in HLA-DQA1 region (OR = 1.43, 95% CI = 1.26-1.63, P = 4.62 × 10-8), and with amino acid Gln at position 53 versus other variants in HLA-DQA1 (OR = 1.36, P = 2.06 × 10-6). The associations with HLA-DQA1*0401 (OR = 1.29, P = 0.03) and rs2040406(G) (OR = 1.68, P = 0.019) persist in mutually adjusted models. The higher risk rs2040406(G) variant for BL is associated with decreased HLA-DQB1 expression in eQTLs in EBV transformed lymphocytes. Our results support the role of HLA variation in the etiology of BL and suggest that a promising area of research might be understanding the link between HLA variation and EBV control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Burkitt / Infecciones por Virus de Epstein-Barr Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Burkitt / Infecciones por Virus de Epstein-Barr Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Commun Biol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido