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The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.
Hamid, Aisha; Gattuso, Hannah; Caglar, Aysu Nora; Pillai, Midhula; Steele, Theresa; Gonzalez, Alexa; Nagel, Katherine; Syed, Mubarak Hussain.
Afiliación
  • Hamid A; Department of Biology, University of New Mexico, 219 Yale Blvd NE, Albuquerque, NM 87131, USA.
  • Gattuso H; Neuroscience Institute, NYU Medical Center, 435 E 30th St., New York, NY 10016, USA.
  • Caglar AN; Department of Biology, University of New Mexico, 219 Yale Blvd NE, Albuquerque, NM 87131, USA.
  • Pillai M; Neuroscience Institute, NYU Medical Center, 435 E 30th St., New York, NY 10016, USA.
  • Steele T; Neuroscience Institute, NYU Medical Center, 435 E 30th St., New York, NY 10016, USA.
  • Gonzalez A; Department of Biology, University of New Mexico, 219 Yale Blvd NE, Albuquerque, NM 87131, USA.
  • Nagel K; Neuroscience Institute, NYU Medical Center, 435 E 30th St., New York, NY 10016, USA. Electronic address: katherine.nagel@nyumc.org.
  • Syed MH; Department of Biology, University of New Mexico, 219 Yale Blvd NE, Albuquerque, NM 87131, USA. Electronic address: flyguy@unm.edu.
Curr Biol ; 34(3): 473-488.e6, 2024 02 05.
Article en En | MEDLINE | ID: mdl-38181792
ABSTRACT
Complex behaviors depend on the precise developmental specification of neuronal circuits, but the relationship between genetic programs for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) is a conserved sensory-motor integration center in insects, which governs many higher-order behaviors and largely derives from a small number of type II neural stem cells (NSCs). Here, we show that Imp, a conserved IGF-II mRNA-binding protein expressed in type II NSCs, plays a role in specifying essential components of CX olfactory navigation circuitry. We show the following (1) that multiple components of olfactory navigation circuitry arise from type II NSCs. (2) Manipulating Imp expression in type II NSCs alters the number and morphology of many of these circuit elements, with the most potent effects on neurons targeting the ventral layers of the fan-shaped body (FB). (3) Imp regulates the specification of Tachykinin-expressing ventral FB input neurons. (4) Imp is required in type II NSCs for establishing proper morphology of the CX neuropil structures. (5) Loss of Imp in type II NSCs abolishes upwind orientation to attractive odor while leaving locomotion and odor-evoked regulation of movement intact. Taken together, our findings establish that a temporally expressed gene can regulate the expression of a complex behavior by developmentally regulating the specification of multiple circuit components and provides a first step toward a developmental dissection of the CX and its roles in behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olfato / Proteínas de Unión al ARN / Proteínas de Drosophila / Drosophila melanogaster / Células-Madre Neurales / Navegación Espacial Límite: Animals Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olfato / Proteínas de Unión al ARN / Proteínas de Drosophila / Drosophila melanogaster / Células-Madre Neurales / Navegación Espacial Límite: Animals Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido