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Sesamol as a potent anticancer compound: from chemistry to cellular interactions.
Kumar, Ajay; Bajaj, Payal; Singh, Brahmjot; Paul, Kapil; Sharma, Pooja; Mehra, Sukanya; Kaur, Pardeep; Jasrotia, Shivam; Kumar, Parveen; Singh, Vipourpreet; Tuli, Hardeep Singh.
Afiliación
  • Kumar A; University Center for Research & Development (UCRD), Biotechnology Engineering & Food Technology, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India. kumar.ajay1250@gmail.com.
  • Bajaj P; Advanced Eye Center, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
  • Singh B; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
  • Paul K; Kanya Maha Vidyalaya, Jalandhar, 144004, Punjab, India.
  • Sharma P; Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
  • Mehra S; P.G. Department of Science, Khalsa College For Women, Amritsar, 143001, Punjab, India.
  • Robin; Regional Water Testing Laboratory, Department of Water Supply and Sanitation, Agilent Technologies India Pvt. Ltd., Amritsar, Punjab, India.
  • Kaur P; Post Graduate Department of Botany, Khalsa College, Amritsar, Punjab, India.
  • Jasrotia S; Department of Biosciences, University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, 140413, India.
  • Kumar P; Department of Chemistry, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India.
  • Rajat; Punjab Biotechnology Incubator (PBTI), Phase VIII, Mohali, 160071, India.
  • Singh V; Coast Mountain College, Prince Rupert, British Columbia, V8J3S8, Canada.
  • Tuli HS; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India.
Naunyn Schmiedebergs Arch Pharmacol ; 397(7): 4961-4979, 2024 07.
Article en En | MEDLINE | ID: mdl-38180556
ABSTRACT
Sesamol (SM), a well-known component isolated from sesame seeds (Sesamum indicum), used in traditional medicines in treating numerous ailments. However, numerous molecular investigations revealed the various mechanisms behind its activity, emphasizing its antiproliferative, anti-inflammatory, and apoptosis-inducing properties, preventing cancer cell spread to distant organs. In several cells derived from various malignant tissues, SM-regulated signal transduction pathways and cellular targets have been identified. This review paper comprehensively describes the anticancer properties of SM and SM-viable anticancer drugs. Additionally, the interactions of this natural substance with standard anticancer drugs are examined, and the benefits of using nanotechnology in SM applications are explored. This makes SM a prime example of how ethnopharmacological knowledge can be applied to the development of contemporary drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Benzodioxoles Límite: Animals / Humans Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Benzodioxoles Límite: Animals / Humans Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania