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Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid technology.
Mashaqbeh, Hadeia; Obaidat, Rana M; Alsmadi, Mo'tasem M.
Afiliación
  • Mashaqbeh H; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
  • Obaidat RM; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
  • Alsmadi MM; Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Drug Dev Ind Pharm ; 50(2): 102-111, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38180038
ABSTRACT
INTRODUCTION AND

PURPOSE:

The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with the tasting buds using insoluble polymers at salivary pH (6.8 - 7.4), like the cationic polymer Eudragit EPO. Supercritical fluid technology is a green synthesis method for preparing pharmaceutical preparations that replace organic solvents with safe supercritical CO2. This study aimed to mask the bitter taste of azithromycin using the supercritical fluid method and a pH-sensitive Eudragit EPO polymer.

METHODS:

A foaming process was investigated for preparing a formulation (TEST), which comprises treating the polymer with supercritical carbon dioxide (CO2) fluid to prepare a taste-masked dosage form without employing organic solvents or flavors.

RESULTS:

The use of the supercritical technique at 40 °C and 10 MPa for 2 h allowed the manufacturing of solvent-free polymeric foam with azithromycin dispersions; the average calculated percentage of apparent volume change was 62.5 ± 5.9% with an average pore diameter of 34.879 Å. The formulated sample showed low drug release in simulated salivary fluid while keeping its crystalline nature. Moreover, clinical studies on healthy subjects showed that the formula successfully masked azithromycin's bitter taste.

CONCLUSIONS:

Overall, it has been shown herein that the supercritical fluid technology foaming method is promising in masking the bitter taste of bitter ingredients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Polimetacrílicos / Gusto / Azitromicina Límite: Child / Humans Idioma: En Revista: Drug Dev Ind Pharm Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Polimetacrílicos / Gusto / Azitromicina Límite: Child / Humans Idioma: En Revista: Drug Dev Ind Pharm Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido