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Comparison of enteral immunonutrition and enteral nutrition in patients undergoing gastric cancer surgery: a systematic review and meta-analysis of randomized, controlled trials.
Li, Ji; Xiang, Qing-Lin; Zhu, Jin-Xian; Zhang, Yu-Xin; Li, Shi-Qiang.
Afiliación
  • Li J; General Surgery, Chongqing Western Hospital, 400051, Chongqing, China.
  • Xiang QL; Department of Gastrointestinal and Breast Surgery, the Chongqing Kaizhou District People's Hospital, Chongqing 405400, China.
  • Zhu JX; General Surgery, Chongqing Western Hospital, 400051, Chongqing, China.
  • Zhang YX; General Surgery, Chongqing Western Hospital, 400051, Chongqing, China.
  • Li SQ; General Surgery, Chongqing Western Hospital, 400051, Chongqing, China.
J Int Med Res ; 52(1): 3000605231220870, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38179793
ABSTRACT

OBJECTIVE:

Enteral immunonutrition is a nutritional intervention that has been studied in postoperative patients with gastric cancer, but its effectiveness is controversial. This study aimed to investigate the effects of enteral immunonutrition and enteral nutrition on immune function in patients who undergo gastric cancer surgery.

METHODS:

We performed a systematic review and meta-analysis. A comprehensive search was conducted in PubMed, Embase, Cochrane, Web of Knowledge, and ClinicalTrials.gov from the inception of the review until 10 March 2023. Twelve studies were included for qualitative and quantitative analyses.

RESULTS:

We studied 1124 patients, including 565 patients in the enteral immunonutrition group and 559 in the enteral nutrition (controls) group. All included randomized, controlled trials were high quality. CD4+ levels, lymphocytes, transferrin concentrations, and systemic inflammatory response syndrome were not significantly different between the enteral immunonutrition and enteral nutrition groups. However, CD8+, immunoglobulins G and M, and proalbumin concentrations, CD4+/CD8+, and infectious complications were significantly higher in the enteral immunonutrition group than in the enteral nutrition group. A sensitivity analysis showed consistent results after excluding each study. Begg's test showed no publication bias.

CONCLUSIONS:

Enteral immunonutrition is an effective nutritional intervention that improves immune function in patients who have undergone gastric cancer surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Procedimientos Quirúrgicos del Sistema Digestivo Tipo de estudio: Clinical_trials / Etiology_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Procedimientos Quirúrgicos del Sistema Digestivo Tipo de estudio: Clinical_trials / Etiology_studies / Qualitative_research / Systematic_reviews Límite: Humans Idioma: En Revista: J Int Med Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido