Your browser doesn't support javascript.
loading
An Insight into Biochemical Characterization and Explorations of Antioxidant, Antibacterial, Cytotoxic, and Antidiabetic Activities by Trachyspermum ammi Nanosuspensions.
Jabeen, Rizwana; Ali, Tayyab; Naeem, Muhammad; Hussain, Fatma; Danish, Subhan; Alahmadi, Tahani Awad; Samdani, Mohammad Shahzad; Ansari, Mohammad Javed.
Afiliación
  • Jabeen R; Clinico-Molecular Biochemistry Laboratory, Department of Biochemistry, Faculty of Sciences, University of Agriculture, 38000 Faisalabad, Pakistan.
  • Ali T; Clinico-Molecular Biochemistry Laboratory, Department of Biochemistry, Faculty of Sciences, University of Agriculture, 38000 Faisalabad, Pakistan.
  • Naeem M; College of Life Science, Hebei Normal University, 050024 Shijiazhuang, Hebei, China.
  • Hussain F; Clinico-Molecular Biochemistry Laboratory, Department of Biochemistry, Faculty of Sciences, University of Agriculture, 38000 Faisalabad, Pakistan.
  • Danish S; Department of Soil Science, Faculty of Agricultural Sciences and Technology, Bahauddin Zakariya University, 60700 Multan, Punjab, Pakistan.
  • Alahmadi TA; Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, P.O. Box: 2925 Riyadh 11461, Saudi Arabia.
  • Samdani MS; College of Science, King Saud University, P.O. Box: 2455 Riyadh 11451, Saudi Arabia.
  • Ansari MJ; Al-Waili foundation of Science, New York, NY 11368, USA.
Front Biosci (Landmark Ed) ; 28(12): 340, 2023 12 25.
Article en En | MEDLINE | ID: mdl-38179777
ABSTRACT

BACKGROUND:

Trachyspermum ammi is a frequently utilized traditional medicinal plant renowned for its pharmacological attributes, particularly in the realm of treating infectious diseases. This current study aims to comprehensively assess the in vitro properties of freshly prepared nanosuspensions derived from Trachyspermum ammi extracts, with a focus on their cost-effective potential in various areas, including antioxidant, antibacterial, cytotoxic, and antidiabetic activities.

METHODS:

Biochemical characterization of T. ammi nanosuspensions by high-performance liquid chromatography (HPLC) and Fourier-transform infrared spectroscopy (FTIR) analyses.

RESULTS:

HPLC analysis revealed the presence of kaempferol and sinapic acid in various amounts at 11.5 ppm and 12.3 ppm, respectively. FTIR analysis of T. ammi powder revealed the presence of alcohols and amines. The assessment of antioxidant activity was conducted using a DPPH scavenging assay, indicating that the nanosuspensions exhibited their highest free radical scavenging activity, reaching 14.9%. Nanosuspensions showed 3.75 ± 3.529.5% biofilm inhibition activity against Escherichia coli. The antidiabetic activity was accessed through antiglycation and α- amylase inhibition assays, while nanosuspension showed the maximum inhibition activity at 25.35 ± 0.912133% and 34.6 ± 1.3675%. Hemolytic activity was also evaluated, and T. ammi nanosuspension showed 22.73 ± 1.539% hemolysis.

CONCLUSIONS:

This nanotechnology approach has established a foundation to produce plant-based nanosuspensions, offering a promising avenue for the biopharmaceutical production of herbal nanomedicines. These nanosuspensions have the potential to enhance bioavailability and can serve as a viable alternative to synthetic formulations.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apiaceae / Ammi / Antineoplásicos Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2023 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Singapur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apiaceae / Ammi / Antineoplásicos Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2023 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Singapur