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Enhanced EPR effects by tumour stromal cell mimicking nanoplatform on invasive pituitary adenoma.
Ma, Junning; Wei, Yin; Zhang, Xiaojian; Lin, Lu; Bao, Youmei; Cao, Hui; Chen, Honghwei; Yu, Jianbo; Yang, Jiqi; Zhang, Yue; Lan, Huimin; Li, XueYang; Qiong, Huang; Yang, Dan; Yu, Yajun; Chen, Jingyao; Zhang, Chengchen; Liu, Li; Chen, Lei; Zhan, Renya; Liu, Fei.
Afiliación
  • Ma J; Zhejiang University School of Medicine, Zhe Jiang, 310003, China.
  • Wei Y; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Zhang X; Department of Neurosurgery of First affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China.
  • Lin L; Sun Yat-Sen University, Guangzhou, 510275, China.
  • Bao Y; Department of Pathology& Pathophysiology and Department of Surgical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Zhe Jiang, 310003, China.
  • Cao H; Zhejiang University School of Medicine, Zhe Jiang, 310003, China.
  • Chen H; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Yu J; Sun Yat-Sen University, Guangzhou, 510275, China.
  • Yang J; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Zhang Y; Sun Yat-Sen University, Guangzhou, 510275, China.
  • Lan H; School of Medicine Yale University, New Haven, CT, 06510, USA.
  • Li X; Department of Neurosurgery of First affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China.
  • Qiong H; Department of Neurosurgery of First affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China.
  • Yang D; Department of Neurosurgery of First affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China.
  • Yu Y; Department of Neurosurgery of First affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China.
  • Chen J; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Zhang C; Sun Yat-Sen University, Guangzhou, 510275, China.
  • Liu L; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Chen L; Sun Yat-Sen University, Guangzhou, 510275, China.
  • Zhan R; Department of Neurosurgery of Fifth affiliated Hospital, SunYat-Sen University Zhuhai, 519000, ZhuHai, China.
  • Liu F; Sun Yat-Sen University, Guangzhou, 510275, China.
Mater Today Bio ; 24: 100895, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38179430
ABSTRACT
Rapid advances in nanomedicine have enabled potential applications in cancer therapy. The enhanced permeability and retention (EPR) effect is the primary rationale for the passive targeting of nanoparticles in oncology. However, growing evidence indicates that the accumulation of nanomaterials via the EPR effect could be more efficient. Inspired by our clinical observation of the Gap Junction connecpion between folliculostellate cells and pituitary adenoma cells, we designed a novel drug delivery system that targets tumours by coating folliculostellate cell (FS) membranes onto PLGA nanoparticles (NPs). The resulting FSNPs, inheriting membrane proteins from the folliculostellate cell membrane, significantly enhanced the EPR effect compared to nanoparticles without cancer cell membranes. We further demonstrated that mitotane encapsulation improved the therapeutic efficacy of mitotane in both heterotopic and orthotopic pituitary adenoma models. Owing to its significant efficacy, our FS cell membrane-coated nanoplatforms has the potential to be translated into clinical applications for the treatment of invasive pituitary adenoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Today Bio Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido