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Insulin Therapy on Bone Macroscopic, Microarchitecture, and MechanicalProperties of Tibia in Diabetic Rats.
Limirio, Pedro Henrique Justino Oliveira; De Oliveira Neto, Nilson Ferreira; Venâncio, Jessyca Figueira; Linhares, Camila Rodrigues Borges; Soares, Priscilla Barbosa Ferreira; Dechichi, Paula.
Afiliación
  • Limirio PHJO; Departamento de Periodontia e Implantodontia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará s/nº, Campus Umuarama, Bloco 4L, Uberlândia, Minas Gerais,38.400-902, Brazil.
  • De Oliveira Neto NF; Departamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
  • Venâncio JF; Departamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
  • Linhares CRB; Departamento de histologia, Integrated Dental Clinic Program, School of Dentistry, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama. Uberlândia, Minas Gerais, 38.400-902, Brazil.
  • Soares PBF; Department of Periodontology and Implantology, University of Uberlândia. Avenida Pará 1720, Campus Umuarama, Bloco 4L, Bairro Umuarama, Uberlândia, Minas Gerais, 38.400-902, Brazil.
  • Dechichi P; Departamento de histologia, Biomedical Science Institute, University of Uberlândia, Avenida Pará 1720, Campus Umuarama, Bloco 2B, Bairro Umuarama,Uberlândia, Minas Gerais, 38.400-902, Brazil.
Curr Diabetes Rev ; 20(9): e030124225214, 2024.
Article en En | MEDLINE | ID: mdl-38178671
ABSTRACT

BACKGROUND:

This study evaluated tibia's macroscopic structure, mechanical properties, and bone microarchitecture in rats with type 1 diabetes mellitus (T1DM).

METHODS:

Eighteen animals were divided into three groups (n=6) Non-diabetic (ND), diabetic (D), and diabetic+insulin (DI). T1DM was induced by streptozotocin; insulin was administered daily (4IU). The animals were euthanized 35 days after induction. The tibiae were removed and analyzed using macroscopic, micro-computed tomography (micro-CT) and three-point bending. The macroscopic analysis measured proximal-distal length (PD), antero-posterior thickness (AP) of proximal (AP-P) and distal (AP-D) epiphysis, and lateral-medial thickness (LM) of proximal (LM-P) and distal (LM-D) epiphysis. Micro-CT analysis closed porosity, tissue mineral density, and cortical thickness. The three-point bending test measured maximum strength, energy, and stiffness.

RESULTS:

The macroscopic analysis showed that D presented smaller measures of length and thickness (AP and AP-P) than ND and DI. More extensive measurements were observed of LM and AP-D thickness in DI than in D. In micro-CT, DI showed larger cortical thickness than D. Mechanical analysis showed lower strength in D than in other groups.

CONCLUSIONS:

T1DM reduces bone growth and mechanical strength. Insulin therapy in diabetic rats improved bone growth and fracture resistance, making diabetic bone similar to normoglycemic animals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Densidad Ósea / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Microtomografía por Rayos X / Hipoglucemiantes / Insulina Límite: Animals Idioma: En Revista: Curr Diabetes Rev Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Densidad Ósea / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Microtomografía por Rayos X / Hipoglucemiantes / Insulina Límite: Animals Idioma: En Revista: Curr Diabetes Rev Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos