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Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System.
Maezawa, M; Inoue, M; Satake, R; Wakabayashi, W; Oura, K; Goto, F; Miyasaka, K; Hirofuji, S; Iwata, M; Suzuki, T; Tanaka, H; Nishida, S; Shimizu, S; Suzuki, A; Iguchi, K; Nakamura, M.
Afiliación
  • Maezawa M; Laboratory of Drug Informatics, Gifu Pharmaceutical Universit.
  • Inoue M; Laboratory of Drug Informatics, Gifu Pharmaceutical University.
  • Satake R; Laboratory of Drug Informatics, Gifu Pharmaceutical University.
  • Wakabayashi W; Laboratory of Drug Informatics , Gifu Pharmaceutical University.
  • Oura K; Laboratory of Drug Informatics, Gifu Pharmaceutical University.
  • Goto F; Laboratory of Drug Informatics, Gics, Gifu Pharmaceutical University.
  • Miyasaka K; Laboratory of Drug Informatics, Gics, Gifu Pharmaceutical University.
  • Hirofuji S; Laboratory of Drug Informatics, Gifu Pharmaceutical University.
  • Iwata M; Laboratory of Drug Informatics, Gifu Pharmaceutical University; Kifune Pharmacy.
  • Suzuki T; Laboratory of Drug Informatics, Gifu Pharmaceutical University; Gifu Prefectural Government.
  • Tanaka H; Laboratory of Drug Informatics, Gifu Pharmaceutical University; Chubu Yakuhin Co. Ltd.
  • Nishida S; Department of Pharmacy, Gifu University Hospital.
  • Shimizu S; Department of Pharmacy, Gifu University Hospital.
  • Suzuki A; Department of Pharmacy, Gifu University Hospital.
  • Iguchi K; Laboratory of Community Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
  • Nakamura M; Laboratory of Drug Informatics, Gifu Pharmaceutical University; Corresponding author: Mitsuhiro Nakamura, Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan mnakamura@gifu-pu. ac. jp.
Pharmazie ; 78(11): 245-250, 2023 Dec 04.
Article en En | MEDLINE | ID: mdl-38178284
ABSTRACT

Objective:

Magnesium oxide is widely used for treating opioid-induced constipation, a serious analgesic-associated problem. Opioid analgesic users are often prescribed non-steroidal anti-inflammatory drugs, which are sometimes combined with acid suppressants to prevent gastrointestinal adverse events. Magnesium preparations combined with acid suppressants may diminish magnesium preparations' laxative effect. This study was aimed at evaluating the effect of magnesium preparations combined with acid suppressants on the incidence of opioid-induced constipation by using the Food and Drug Administration Adverse Event Reporting System.

Methods:

Adverse events were defined per the Medical Dictionary for Regulatory Activities; the term 'constipation (preferred term code 10010774)' was used for analysis. After adjusting for patient background factors using propensity score matching, acid suppressants' effect on constipation incidence was evaluated in opioid users prescribed magnesium preparations alone as laxatives by using a test for independence. Key

Findings:

The Food and Drug Administration Adverse Event Reporting System contains 14,475,614 reports for January 2004 to December 2021. Significantly increased constipation incidence was related to magnesium preparations combined with acid suppressants, especially proton pump inhibitors (P < 0.0001, McNemar's test).

Conclusion:

Magnesium preparations combined with acid suppressants may diminish magnesium preparations' laxative effect; healthcare professionals should pay attention to this issue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Laxativos / Estreñimiento Inducido por Opioides Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2023 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Laxativos / Estreñimiento Inducido por Opioides Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2023 Tipo del documento: Article Pais de publicación: Alemania