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Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity.
Bonazzi, Erica; Bretin, Alexis; Vigué, Lucile; Hao, Fuhua; Patterson, Andrew D; Gewirtz, Andrew T; Chassaing, Benoit.
Afiliación
  • Bonazzi E; INSERM U1016, Team "Mucosal Microbiota in Chronic Inflammatory Diseases", CNRS UMR10 8104, Université Paris Cité, Paris, France.
  • Bretin A; Institute for Biomedical Sciences, Centre for Inflammation, Immunity and Infection, Digestive Disease Research Group, Georgia State University, Atlanta, GA, USA.
  • Vigué L; INSERM U1016, Team "Robustness and Evolvability of Life", CNRS UMR10 8104, Université Paris Cité, Paris, France.
  • Hao F; Department of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA, USA.
  • Patterson AD; INSERM U1016, Team "Robustness and Evolvability of Life", CNRS UMR10 8104, Université Paris Cité, Paris, France.
  • Gewirtz AT; Institute for Biomedical Sciences, Centre for Inflammation, Immunity and Infection, Digestive Disease Research Group, Georgia State University, Atlanta, GA, USA.
  • Chassaing B; INSERM U1016, Team "Mucosal Microbiota in Chronic Inflammatory Diseases", CNRS UMR10 8104, Université Paris Cité, Paris, France. benoit.chassaing@inserm.fr.
Microbiome ; 12(1): 5, 2024 Jan 05.
Article en En | MEDLINE | ID: mdl-38178260
ABSTRACT

BACKGROUND:

The observation that the intestinal microbiota is  central in the development of IBD suggests that dietary fiber, the microbiota's primary source of nourishment, could play a central role in these diseases. Accordingly, enriching diets with specific soluble fibers remodels microbiota and modulates colitis sensitivity. In humans, a recent study suggests that the microbiota of select IBD patients might influence the impacts they would experience upon fiber exposure. We sought here to define the extent to which individual microbiotas varied in their responsiveness to purified soluble fiber inulin and psyllium. Moreover, the extent to which such variance might impact proneness to colitis.

RESULTS:

We observed a high level of inter-individual variation in microbiota responsiveness to fiber inulin and psyllium while microbiotas from select donors exhibited stark fiber-induced modulation in composition, pro-inflammatory potential, and metabolomic profile, others were only minimally impacted. Mice transplanted with fiber-sensitive microbiomes exhibited colitis highly modulated by soluble fiber consumption, while mice receiving fiber-resistant microbiotas displayed colitis severity irrespective of fiber exposure.

CONCLUSION:

The extent to which select soluble fibers alter proneness to colitis is highly influenced by an individual's microbiota composition and further investigation of individual microbiota responsiveness toward specific dietary fiber could pave the way to personalized fiber-based intervention, both in IBD patients and healthy individuals. Video Abstract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psyllium / Enfermedades Inflamatorias del Intestino / Colitis / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Microbiome Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psyllium / Enfermedades Inflamatorias del Intestino / Colitis / Microbioma Gastrointestinal Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Microbiome Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido