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Predicting personal PAH exposure using high dimensional questionnaire and wristband data.
McLarnan, Sarah M; Bramer, Lisa M; Dixon, Holly M; Scott, Richard P; Calero, Lehyla; Holmes, Darrell; Gibson, Elizabeth A; Cavalier, Haleigh M; Rohlman, Diana; Miller, Rachel L; Kincl, Laurel; Waters, Katrina M; Anderson, Kim A; Herbstman, Julie B.
Afiliación
  • McLarnan SM; Department of Environmental Health Sciences, Columbia University, Columbia Center for Children's Environmental Health, Mailman School of Public Health, New York City, NY, USA. smm2316@cumc.columbia.edu.
  • Bramer LM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
  • Dixon HM; Environmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.
  • Scott RP; Environmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.
  • Calero L; Department of Environmental Health Sciences, Columbia University, Columbia Center for Children's Environmental Health, Mailman School of Public Health, New York City, NY, USA.
  • Holmes D; Department of Environmental Health Sciences, Columbia University, Columbia Center for Children's Environmental Health, Mailman School of Public Health, New York City, NY, USA.
  • Gibson EA; Department of Environmental Health Sciences, Columbia University, Columbia Center for Children's Environmental Health, Mailman School of Public Health, New York City, NY, USA.
  • Cavalier HM; Department of Environmental Health Sciences, Columbia University, Columbia Center for Children's Environmental Health, Mailman School of Public Health, New York City, NY, USA.
  • Rohlman D; Oregon State University, College of Public Health and Human Sciences, Corvallis, OR, USA.
  • Miller RL; Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
  • Kincl L; Oregon State University, College of Public Health and Human Sciences, Corvallis, OR, USA.
  • Waters KM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
  • Anderson KA; Environmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.
  • Herbstman JB; Environmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.
J Expo Sci Environ Epidemiol ; 34(4): 679-687, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38177333
ABSTRACT

BACKGROUND:

Polycyclic aromatic hydrocarbons (PAHs) are a class of pervasive environmental pollutants with a variety of known health effects. While significant work has been completed to estimate personal exposure to PAHs, less has been done to identify sources of these exposures. Comprehensive characterization of reported sources of personal PAH exposure is a critical step to more easily identify individuals at risk of high levels of exposure and for developing targeted interventions based on source of exposure.

OBJECTIVE:

In this study, we leverage data from a New York (NY)-based birth cohort to identify personal characteristics or behaviors associated with personal PAH exposure and develop models for the prediction of PAH exposure.

METHODS:

We quantified 61 PAHs measured using silicone wristband samplers in association with 75 questionnaire variables from 177 pregnant individuals. We evaluated univariate associations between each compound and questionnaire variable, conducted regression tree analysis for each PAH compound and completed a principal component analysis of for each participant's entire PAH exposure profile to determine the predictors of PAH levels.

RESULTS:

Regression tree analyses of individual compounds and exposure mixture identified income, time spent outdoors, maternal age, country of birth, transportation type, and season as the variables most frequently predictive of exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Exposición a Riesgos Ambientales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Expo Sci Environ Epidemiol Asunto de la revista: EPIDEMIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocarburos Policíclicos Aromáticos / Exposición a Riesgos Ambientales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Expo Sci Environ Epidemiol Asunto de la revista: EPIDEMIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos