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Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
Little, Alexander S; Younker, Isaac T; Schechter, Matthew S; Bernardino, Paola Nol; Méheust, Raphaël; Stemczynski, Joshua; Scorza, Kaylie; Mullowney, Michael W; Sharan, Deepti; Waligurski, Emily; Smith, Rita; Ramanswamy, Ramanujam; Leiter, William; Moran, David; McMillin, Mary; Odenwald, Matthew A; Iavarone, Anthony T; Sidebottom, Ashley M; Sundararajan, Anitha; Pamer, Eric G; Eren, A Murat; Light, Samuel H.
Afiliación
  • Little AS; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Younker IT; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Schechter MS; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Bernardino PN; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Méheust R; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Stemczynski J; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Scorza K; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Mullowney MW; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Sharan D; Génomique Métabolique, CEA, Genoscope, Institut François Jacob, Université d'Évry, Université Paris-Saclay, CNRS, Evry, France.
  • Waligurski E; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Smith R; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Ramanswamy R; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Leiter W; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Moran D; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • McMillin M; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Odenwald MA; Department of Microbiology, University of Chicago, Chicago, IL, USA.
  • Iavarone AT; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Sidebottom AM; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Sundararajan A; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Pamer EG; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Eren AM; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
  • Light SH; Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Nat Microbiol ; 9(1): 55-69, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38177297
ABSTRACT
Respiratory reductases enable microorganisms to use molecules present in anaerobic ecosystems as energy-generating respiratory electron acceptors. Here we identify three taxonomically distinct families of human gut bacteria (Burkholderiaceae, Eggerthellaceae and Erysipelotrichaceae) that encode large arsenals of tens to hundreds of respiratory-like reductases per genome. Screening species from each family (Sutterella wadsworthensis, Eggerthella lenta and Holdemania filiformis), we discover 22 metabolites used as respiratory electron acceptors in a species-specific manner. Identified reactions transform multiple classes of dietary- and host-derived metabolites, including bioactive molecules resveratrol and itaconate. Products of identified respiratory metabolisms highlight poorly characterized compounds, such as the itaconate-derived 2-methylsuccinate. Reductase substrate profiling defines enzyme-substrate pairs and reveals a complex picture of reductase evolution, providing evidence that reductases with specificities for related cinnamate substrates independently emerged at least four times. These studies thus establish an exceptionally versatile form of anaerobic respiration that directly links microbial energy metabolism to the gut metabolome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Ecosistema Límite: Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Ecosistema Límite: Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido