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An injectable collagen peptide-based hydrogel with desirable antibacterial, self-healing and wound-healing properties based on multiple-dynamic crosslinking.
Li, Jing; Zhai, Yong-Nian; Xu, Jing-Ping; Zhu, Xiao-Yun; Yang, Hao-Ran; Che, Huan-Jie; Liu, Cheng-Kun; Qu, Jian-Bo.
Afiliación
  • Li J; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Zhai YN; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Xu JP; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Zhu XY; Qingdao Kehai Jiantang Biology Co., Ltd, Qingdao 266580, PR China.
  • Yang HR; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Che HJ; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Liu CK; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China.
  • Qu JB; College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China. Electronic address: jbqu@upc.edu.cn.
Int J Biol Macromol ; 259(Pt 1): 129006, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38176492
ABSTRACT
Conventional collagen-based hydrogels as wound dressing materials are usually lack of antibacterial activity and easily broken when encountering external forces. In this work, we developed a collagen peptide-based hydrogel as a wound dressing, which was composed of adipic acid dihydrazide functionalized collagen peptide (Col-ADH), oxidized dextran (ODex), polyvinyl alcohol (PVA) and borax via multiple-dynamic reversible bonds (acylhydrazone, amine, borate ester and hydrogen bonds). The injectable hydrogel exhibited satisfactory self-healing ability, antibacterial activity, mechanical strength, as well as good biocompatibility and biodegradability. In vivo experiments demonstrated the rapid hemostasis, accelerated cell migration, and promoted wound healing capacities of the hydrogel. These results indicate that the multifunctional collagen peptide-based hydrogel has great potentials in the field of wound dressings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Prunella Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Prunella Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos