Homozygous Loss of CDKN2 in Primary Cutaneous CD8(+) Lymphoma NOS.
Am J Dermatopathol
; 46(3): 147-152, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38175704
ABSTRACT
ABSTRACT Primary cutaneous acral CD8(+) lymphoma (AL) has been accepted as primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder in the revised WHO and updated WHO-EORTC lymphoma classifications. Commonly arising on the ears and comprising a clonal cytotoxic CD8 + T-cell infiltrate, almost all cases follow an indolent clinical course. A single aggressive case reported in the literature had a deletion at the CDKN2 locus at 9p21. We report an atypical CD8 + T-cell proliferation arising on the chest of an elderly man who had some similarities to AL but with a very high proliferation rate, absent p16 protein expression, and homozygous loss of the CDKN2 locus using FISH analysis. A diagnosis of peripheral T-cell lymphoma not otherwise specified (PTCL NOS) was preferred. Analyses of 4 cases of AL demonstrated often low p16 protein expression but intact CDKN2 loci. This case raises the problems of the boundaries between AL and PTCL NOS, and a possible role in the loss of p16 function in pathogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfoma Cutáneo de Células T
/
Linfoma de Células T Periférico
Límite:
Humans
/
Male
Idioma:
En
Revista:
Am J Dermatopathol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos