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The non-HDL-C/HDL-C ratio is a strong and independent predictor of the no-reflow phenomenon in patients with ST-elevation myocardial infarction.
Toprak, Kenan; Kaplangoray, Mustafa; Akyol, Selahattin; Inanir, Mehmet; Memioglu, Tolga; Tascanov, Mustafa Begenç; Altiparmak, Ibrahim Halil; Biçer, Asuman; Demirbag, Recep.
Afiliación
  • Toprak K; Department of Cardiology, Harran University, Sanliurfa, Turkey.
  • Kaplangoray M; Department of Cardiology, Seyh Edebali University, Bilecik, Turkey.
  • Akyol S; Department of Cardiology, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
  • Inanir M; Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey.
  • Memioglu T; Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey.
  • Tascanov MB; Department of Cardiology, Harran University, Sanliurfa, Turkey.
  • Altiparmak IH; Department of Cardiology, Harran University, Sanliurfa, Turkey.
  • Biçer A; Department of Cardiology, Harran University, Sanliurfa, Turkey.
  • Demirbag R; Department of Cardiology, Harran University, Sanliurfa, Turkey.
Acta Cardiol ; 79(2): 194-205, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38174719
ABSTRACT

BACKGROUND:

No-reflow (NR) is the inability to achieve adequate myocardial perfusion despite successful restoration of attegrade blood flow in the infarct-related artery after primary percutaneous coronary intervention. The non-HDL-C/HDL-C ratio has been shown to be superior to conventional lipid markers in predicting most cardiovascular diseases. In this study, we wanted to reveal the predictive value of the NR by comparing the Non-HDL-C/HDL-C ratio with traditional and non-traditional lipid markers in patients who underwent primary percutaneous coronary intervention (pPCI) due to ST-elevation myocardial infarction (STEMI).

METHODS:

A total of 1284 consecutive patients who underwent pPCI for STEMI were included in this study. Traditional lipid profiles were detected and non-traditional lipid indices were calculated. Patients were classified as groups with and without NR and compared in terms of lipid profiles.

RESULTS:

No-reflow was seen in 18.8% of the patients. SYNTAX score, maximal stent length, high thrombus burden, atherogenic index of plasma and non-HDL-C/HDL-C ratio were determined as independent predictors for NR (p < 0.05, for all). The non-HDL-C/HDL-C ratio predicts the development of NR in STEMI patients with 71% sensitivity and 67% specificity at the best cut-off value. In ROC curve analysis, the non-HDL-C/HDL-C ratio was superior to traditional and non-traditional lipid markers in predicting NR (p < 0.05, for all).

CONCLUSION:

The non-HDL-C/HDL-C ratio can be a strong and independent predictor of NR in STEMI patients and and therefore non-HDL-C/HDL-C ratio may be a useful lipid-based biomarker that can be used in clinical practice to improve the accuracy of risk assessment in patients with STEMI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenómeno de no Reflujo / Intervención Coronaria Percutánea / Infarto del Miocardio con Elevación del ST Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenómeno de no Reflujo / Intervención Coronaria Percutánea / Infarto del Miocardio con Elevación del ST Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Acta Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido