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Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance.
Fan, Yajie; Yan, Zhipeng; Li, Tingting; Li, Aolin; Fan, Xinbiao; Qi, Zhongwen; Zhang, Junping.
Afiliación
  • Fan Y; Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Yan Z; Department of Cardiovascular, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
  • Li T; Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Li A; Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Fan X; Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Qi Z; Department of Cardiovascular, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Zhang J; Institute of Gerontology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Diabetes Metab J ; 48(1): 19-36, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38173376
ABSTRACT
Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Diabetes Mellitus / Cardiopatías Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Diabetes Metab J Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Diabetes Mellitus / Cardiopatías Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Diabetes Metab J Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Corea del Sur