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Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy.
Malik, Parth; Bernela, Manju; Seth, Mahima; Kaushal, Priya; Mukherjee, Tapan Kumar.
Afiliación
  • Malik P; School of Chemical Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India.
  • Bernela M; Department of Biotechnology, Guru Nanak Dev University, Amritsar-143001, India.
  • Seth M; Biotechnology Division, CSIR-IHBT, Palampur, Himachal Pradesh, India.
  • Kaushal P; Biotechnology Division, CSIR-IHBT, Palampur, Himachal Pradesh, India.
  • Mukherjee TK; Institute of Biotechnology, Amity University, Kolkata 700156, West Bengal, India.
Curr Pharm Des ; 29(37): 2954-2976, 2023.
Article en En | MEDLINE | ID: mdl-38173051
ABSTRACT

BACKGROUND:

In the plant kingdom, flavonoids are widely distributed with multifunctional immunomodulatory actions. Hesperetin (HST) remains one of the well-studied compounds in this domain, initially perceived in citrus plants as an aglycone derivative of hesperidin (HDN). OBSERVATIONS Natural origin, low in vivo toxicity, and pleiotropic functional essence are the foremost fascinations for HST use as an anticancer drug. However, low aqueous solubility accompanied with a prompt degradation by intestinal and hepatocellular enzymes impairs HST physiological absorption. MOTIVATION Remedies attempted herein comprise the synthesis of derivatives and nanocarrier (NC)-mediated delivery. As the derivative synthesis aggravates the structural complexity, NC-driven HST delivery has emerged as a sustainable approach for its sustained release. Recent interest in HST has been due to its significant anticancer potential, characterized via inhibited cell division (proliferation), new blood vessel formation (angiogenesis), forceful occupation of neighboring cell's space (invasion), migration to erstwhile physiological locations (metastasis) and apoptotic induction. The sensitization of chemotherapeutic drugs (CDs) by HST is driven via stoichiometrically regulated synergistic actions. Purpose and

Conclusion:

This article sheds light on HST structure-function correlation and pleiotropic anticancer mechanisms, in unaided and NC-administered delivery in singular and with CDs synergy. The discussion could streamline the HST usefulness and long-term anticancer efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hesperidina Límite: Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hesperidina Límite: Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos