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Causal relationships between atopic dermatitis and psychiatric disorders: a bidirectional two-sample Mendelian randomization study.
Cao, Suqi; Zhang, Zicheng; Liu, Lei; Li, Yin; Li, Wei; Li, Yunling; Wu, Dingfeng.
Afiliación
  • Cao S; National Center, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, People's Republic of China.
  • Zhang Z; School of Biomedical Engineering, School of Information and Communication Engineering, Hainan University, Haikou, 570228, People's Republic of China.
  • Liu L; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
  • Li Y; Hainan Institute of Real World Data, Haikou, 570228, People's Republic of China.
  • Li W; Department of Gastroenterology, School of Life Sciences and Technology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, People's Republic of China.
  • Li Y; Department of Dermatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310053, People's Republic of China.
  • Wu D; Department of Dermatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310053, People's Republic of China.
BMC Psychiatry ; 24(1): 16, 2024 01 03.
Article en En | MEDLINE | ID: mdl-38172785
ABSTRACT

BACKGROUND:

Observational studies have suggested the potential associations between atopic dermatitis (AD) and psychiatric disorders. However, the causal relationship between them remains uncertain. This study aimed to evaluate the potential bidirectional causal relationship between AD and psychiatric disorders, including autism spectrum disorder (ASD), major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), anorexia nervosa (AN), Tourette syndrome (TS), schizophrenia, and anxiety.

METHODS:

Bidirectional two-sample Mendelian randomization (MR) was employed to elucidate the causality between AD and psychiatric disorders, using summary statistics from the most comprehensive genome-wide association studies conducted on AD (Ncases = 60,653, Ncontrols = 804,329). Psychiatric disorders were derived from the Psychiatric Genomics Consortium and were independent of AD data sources. The MR analysis entailed the implementation of multiple methods, including the inverse variance weighted method, MR-Egger regression method, weighted median method, simple mode method, and weighted mode method.

RESULTS:

Bidirectional two-sample MR analysis uncovered significant causal associations between AD and severe psychiatric disorders. Specifically, liability to AD was associated with increased risk of ADHD (OR = 1.116; 95% CI [1.009, 1.234]; P = 0.033) and ASD (OR = 1.131; 95% CI [1.023, 1.251]; P = 0.016). Additionally, evidence suggested that liability to ADHD (OR = 1.112; 95% CI [1.094, 1.130]; P = 9.20e-40), liability to AN (OR = 1.1; 95% CI [1.068, 1.134]; P = 4.45e-10) and liability to BD (OR = 1.067; 95% CI [1.009, 1.128]; P = 0.023) were associated with an increased risk of AD. Only the causal association between AD and ASD was independent of the reverse effect bias. These causal associations were robust and not affected by biases of heterogeneity and horizontal pleiotropy.

CONCLUSIONS:

Our study emphasizes the significant causal association between AD and an increased risk of ASD, and also identifying BD and AN as risk factors for AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Trastorno Depresivo Mayor / Dermatitis Atópica / Trastorno del Espectro Autista Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Trastorno Depresivo Mayor / Dermatitis Atópica / Trastorno del Espectro Autista Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido