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Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review.
Helbing, Dario Lucas; Dommaschk, Eva-Maria; Danyeli, Lena Vera; Liepinsh, Edgars; Refisch, Alexander; Sen, Zümrüt Duygu; Zvejniece, Liga; Rocktäschel, Tonia; Stabenow, Leonie Karoline; Schiöth, Helgi B; Walter, Martin; Dambrova, Maija; Besteher, Bianca.
Afiliación
  • Helbing DL; Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07743, Jena, Germany.
  • Dommaschk EM; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits, Underlying Mental Health (C-I-R-C), Jena, Magdeburg, Halle, Germany.
  • Danyeli LV; German Center for Mental Health (DZPG), Site Halle, Jena, Magdeburg, Germany.
  • Liepinsh E; Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
  • Refisch A; Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University Jena, 07745, Jena, Germany.
  • Sen ZD; Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07743, Jena, Germany.
  • Zvejniece L; Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07743, Jena, Germany.
  • Rocktäschel T; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits, Underlying Mental Health (C-I-R-C), Jena, Magdeburg, Halle, Germany.
  • Stabenow LK; Department of Psychiatry and Psychotherapy, University Tübingen, Tübingen, Germany.
  • Schiöth HB; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Riga, Latvia.
  • Walter M; Faculty of Pharmacy, Riga Stradins University, Riga, Latvia.
  • Dambrova M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07743, Jena, Germany.
  • Besteher B; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits, Underlying Mental Health (C-I-R-C), Jena, Magdeburg, Halle, Germany.
Eur Arch Psychiatry Clin Neurosci ; 2024 Jan 03.
Article en En | MEDLINE | ID: mdl-38172332
ABSTRACT
Post-acute sequelae of COVID-19 can present as multi-organ pathology, with neuropsychiatric symptoms being the most common symptom complex, characterizing long COVID as a syndrome with a significant disease burden for affected individuals. Several typical symptoms of long COVID, such as fatigue, depressive symptoms and cognitive impairment, are also key features of other psychiatric disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and major depressive disorder (MDD). However, clinically successful treatment strategies are still lacking and are often inspired by treatment options for diseases with similar clinical presentations, such as ME/CFS. Acetylcarnitine, the shortest metabolite of a class of fatty acid metabolites called acylcarnitines and one of the most abundant blood metabolites in humans can be used as a dietary/nutritional supplement with proven clinical efficacy in the treatment of MDD, ME/CFS and other neuropsychiatric disorders. Basic research in recent decades has established acylcarnitines in general, and acetylcarnitine in particular, as important regulators and indicators of mitochondrial function and other physiological processes such as neuroinflammation and energy production pathways. In this review, we will compare the clinical basis of neuropsychiatric long COVID with other fatigue-associated diseases. We will also review common molecular disease mechanisms associated with altered acetylcarnitine metabolism and the potential of acetylcarnitine to interfere with these as a therapeutic agent. Finally, we will review the current evidence for acetylcarnitine as a supplement in the treatment of fatigue-associated diseases and propose future research strategies to investigate the potential of acetylcarnitine as a treatment option for long COVID.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania