Your browser doesn't support javascript.
loading
Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study.
Coppola, L; Smaldone, G; Grimaldi, A M; Estraneo, A; Magliacano, A; Soddu, A; Ciccarelli, G; Salvatore, M; Cavaliere, C.
Afiliación
  • Coppola L; IRCCS Synlab SDN, Naples, Italy. luigi.coppola@synlab.it.
  • Smaldone G; IRCCS Synlab SDN, Naples, Italy.
  • Grimaldi AM; IRCCS Synlab SDN, Naples, Italy.
  • Estraneo A; Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Don Carlo Gnocchi, Florence, Italy.
  • Magliacano A; Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Don Carlo Gnocchi, Florence, Italy.
  • Soddu A; Department of Physics and Astronomy, Western Institute of Neuroscience, University of Western Ontario, London, ON, Canada.
  • Ciccarelli G; IRCCS Synlab SDN, Naples, Italy.
  • Salvatore M; IRCCS Synlab SDN, Naples, Italy.
  • Cavaliere C; IRCCS Synlab SDN, Naples, Italy.
Sci Rep ; 14(1): 341, 2024 01 03.
Article en En | MEDLINE | ID: mdl-38172270
ABSTRACT
Although clinical examination still represents the gold standard for the differential diagnosis of prolonged disorders of consciousness (pDoC), the introduction of innovative markers is essential for diagnosis and prognosis, due to the problem of covert cognition. We evaluated the brain-derived neurotrophic factor protein (BDNF) and the soluble cell adhesion molecules proteins (CAMs) in a cohort of prolonged disorders of consciousness patients to identify a possible application in the clinical context. Furthermore, peripheral blood determinations were correlated with imaging parameters such as white matter hyperintensities (WMH), cranial standardized uptake value (cSUV), electroencephalography (EEG) data and clinical setting. Our results, although preliminary, identify BDNF as a possible blood marker for the diagnosis of pDoC (p value 0.001), the soluble CAMs proteins CD44, Vcam-1, E-selectin (p value < 0.01) and Icam-3 (p value < 0.05) showed a higher peripheral blood value in pDoC compared with control. Finally, soluble Ncam protein could find useful applications in the clinical evolution of the pDoC, showing high levels in the MCS and EMCS subgroups (p value < 0. 001) compared to VS/UWS.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Conciencia / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Conciencia / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido