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The polyketide to fatty acid transition in the evolution of animal lipid metabolism.
Lin, Zhenjian; Li, Feng; Krug, Patrick J; Schmidt, Eric W.
Afiliación
  • Lin Z; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
  • Li F; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
  • Krug PJ; Department of Biological Sciences, California State University, Los Angeles, CA, 90032, USA.
  • Schmidt EW; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA. ews1@utah.edu.
Nat Commun ; 15(1): 236, 2024 Jan 03.
Article en En | MEDLINE | ID: mdl-38172109
ABSTRACT
Animals synthesize simple lipids using a distinct fatty acid synthase (FAS) related to the type I polyketide synthase (PKS) enzymes that produce complex specialized metabolites. The evolutionary origin of the animal FAS and its relationship to the diversity of PKSs remain unclear despite the critical role of lipid synthesis in cellular metabolism. Recently, an animal FAS-like PKS (AFPK) was identified in sacoglossan molluscs. Here, we explore the phylogenetic distribution of AFPKs and other PKS and FAS enzymes across the tree of life. We found AFPKs widely distributed in arthropods and molluscs (>6300 newly described AFPK sequences). The AFPKs form a clade with the animal FAS, providing an evolutionary link bridging the type I PKSs and the animal FAS. We found molluscan AFPK diversification correlated with shell loss, suggesting AFPKs provide a chemical defense. Arthropods have few or no PKSs, but our results indicate AFPKs contributed to their ecological and evolutionary success by facilitating branched hydrocarbon and pheromone biosynthesis. Although animal metabolism is well studied, surprising new metabolic enzyme classes such as AFPKs await discovery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Policétidos Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Policétidos Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido