Correlation between Pancreatic Fat Deposition and Metabolic Syndrome: Relationships with Location in the Pancreas and Sex.

Ookura, Ryusuke; Usuki, Noriaki; Miki, Yukio

Ookura, Ryusuke; Usuki, Noriaki; Miki, Yukio.

Afiliación

Ookura R; Department of Diagnostic and Interventional Radiology, Japan Community Healthcare Organization Osaka Hospital, Japan.
Usuki N; Department of Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka Metropolitan University, Japan.
Miki Y; Department of Diagnostic and Interventional Radiology, Japan Community Healthcare Organization Osaka Hospital, Japan.

Intern Med ; 63(15): 2113-2123, 2024 Aug 01.

Article en En | MEDLINE | ID: mdl-38171856

ABSTRACT

ABSTRACT

Objective To investigate the correlation between pancreatic fat deposition and metabolic syndrome (MetS) parameters, focusing on the locations of fat deposition in the pancreas and sex differences. Methods Degrees of fat deposition in the head, body, and tail of the pancreas were evaluated using computed tomography (CT). We examined the relationships between pancreatic fat deposition and the age, body mass index (BMI), visceral and subcutaneous fat, serum lipid profiles, hepatic steatosis, diabetes mellitus (DM), and hypertension (HTN). Results In this retrospective study, greater fat deposition was associated with a higher BMI, visceral and subcutaneous fat accumulation, and hepatic steatosis, with the pancreatic head showing the strongest correlation. Correlations of pancreatic fat deposition with the BMI and visceral and subcutaneous fat accumulation were stronger in females than in males, while correlations with hepatic steatosis were stronger in males than in females. In addition, a multivariate analysis did not suggest a direct causal relationship between pancreatic fat deposition and DM and HTN, but there was a significant correlation between pancreatic fat deposition in the pancreatic head and visceral fat area. Conclusion Pancreatic fat deposition, as evaluated by CT, especially in the part of the pancreatic head adjacent to the ampulla of Vater, is a sensitive indicator of MetS. The correlations between pancreatic fat deposition and MetS parameters tended to be stronger in females than in males. These results may help further elucidate the pathophysiology of MetS and provide opportunities for its diagnosis.

Asunto(s)

Síndrome Metabólico; Páncreas; Tomografía Computarizada por Rayos X; Humanos; Síndrome Metabólico/diagnóstico; Masculino; Femenino; Persona de Mediana Edad; Páncreas/diagnóstico por imagen; Páncreas/metabolismo; Estudios Retrospectivos; Anciano; Adulto; Factores Sexuales; Tejido Adiposo/diagnóstico por imagen; Tejido Adiposo/metabolismo; Índice de Masa Corporal; Grasa Intraabdominal/diagnóstico por imagen; Grasa Intraabdominal/metabolismo; Hígado Graso/diagnóstico por imagen

Palabras clave

diabetes mellitus; metabolic syndrome; non-alcoholic fatty pancreas disease; obesity; pancreatic steatosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Tomografía Computarizada por Rayos X / Síndrome Metabólico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón

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