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Tetraclinis articulata (Vahl) Mast. essential oil as a promising source of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory and dermatoprotective properties: In vitro and in silico evidence.
El Hachlafi, Naoufal; Fikri-Benbrahim, Kawtar; Al-Mijalli, Samiah Hamad; Elbouzidi, Amine; Jeddi, Mohamed; Abdallah, Emad M; Assaggaf, Hamza; Bouyahya, Abdelhakim; Alnasser, Sulaiman Mohammed; Attar, Ammar; Goh, Khang Wen; Ming, Long Chiau; Ong, Seng-Kai; Mrabti, Hanae Naceiri; Chahdi, Fouad Ouazzani.
Afiliación
  • El Hachlafi N; Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Imouzzer Road, Fez P.O. Box 2202, Morocco.
  • Fikri-Benbrahim K; Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Imouzzer Road, Fez P.O. Box 2202, Morocco.
  • Al-Mijalli SH; Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 17 Riyadh 11671, Saudi Arabia.
  • Elbouzidi A; Laboratoire D'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Université Mohammed Premier, Oujda, 60000, Morocco.
  • Jeddi M; Euro-Mediterranean University of Fes (UEMF), Fes, Morocco.
  • Abdallah EM; Laboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies Faculty, Sidi Mohamed Ben Abdellah University, Imouzzer Road, Fez P.O. Box 2202, Morocco.
  • Assaggaf H; Department of Science Laboratories, College of Science and Arts, Qassim University, Ar Rass 51921, Saudi Arabia.
  • Bouyahya A; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
  • Alnasser SM; Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University, Rabat, 10106, Morocco.
  • Attar A; Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Buraidah, 51452, Saudi Arabia.
  • Goh KW; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
  • Ming LC; Faculty of Data Science and Information Technology, INTI International University, 71800, Nilai, Malaysia.
  • Ong SK; School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
  • Mrabti HN; School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
  • Chahdi FO; High Institute of Nursing Professions and Health Techniques Casablanca, Morocco.
Heliyon ; 10(1): e23084, 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-38169772
ABSTRACT
Tetraclinis articulata is a known traditional medicinal plant used to manage various ailments, such as diabetes, rheumatism and infectious diseases. This study aims to determine the chemical constituents of T. articulata essential oil (EO) and to evaluate its in vitro antibacterial, anti-candidal, antioxidant, anti-inflammatory and dermatoprotective properties. In addition, a computational docking approach was used to predict the potential antioxidant, antibacterial, antifungal, anti-inflammatory, and cytotoxic properties of the identified compounds. The volatile oil obtained by hydrodistillation was characterized using gas chromatography-mass spectrometry (GC-MS). The antioxidant activity of T. articulata EO was investigated using three complementary assays DPPH, ABTS and FRAP. Lipoxygenase (5-LOX) and tyrosinase enzymes were used to assess the anti-inflammatory and dermatoprotective effects of this oil. Moreover, disc-diffusion technique, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays were employed for the antimicrobial screening. The GC-MS analysis revealed that bornyl acetate (41.80 %), α-pinene (17.97 %) and camphor (15.97 %) are the major components of the studied EO. Moreover, T. articulata EO has exhibited promising antioxidant effect on FRAP, DPPH, and ABTS experiments. It also significantly inhibited 5-LOX (IC50 = 67.82 ± 0.03 µg/mL) and tyrosinase (IC50 = 211.93 ± 0.02 µg/mL). The results of MIC and MBC assays indicated that T. articulata EO is able to inhibit the growth of all tested bacteria (Gram + and Gram -) and Candida species. The ratio of tolerance level indicated that the tested oil was bactericidal against the Gram + bacteria and Candida species, whereas it has a bacteriostatic behavior against the Gram- bacteria. In light of these findings, T. articulata EO may be suggested as a potential pharmaceutical agent to prevent inflammation and skin problems and may serve as a natural antimicrobial and antioxidant alternative for sustainable application in food products.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Reino Unido