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Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics.
Shin, Eunjeong; Zhang, Yongzhen; Zhou, Jieqiang; Lang, Yinzhi; Sayed, Alaa R M; Werkman, Carolin; Jiao, Yuanyuan; Kumaraswamy, Monika; Bulman, Zackery P; Luna, Brian M; Bulitta, Jürgen B.
Afiliación
  • Shin E; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Zhang Y; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Zhou J; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Lang Y; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Sayed ARM; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Werkman C; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA.
  • Jiao Y; Peking University Cancer Hospital, Beijing, China.
  • Kumaraswamy M; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Bulman ZP; Infectious Diseases Section, VA San Diego Healthcare System, San Diego, California, USA.
  • Luna BM; Department of Pharmacy Practice, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA.
  • Bulitta JB; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Antimicrob Agents Chemother ; 68(2): e0139323, 2024 Feb 07.
Article en En | MEDLINE | ID: mdl-38169309
ABSTRACT
Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunted, but overall exposures were moderately high.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoglicósidos / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoglicósidos / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos