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The clinical efficacy and safety of granulocyte and monocyte adsorptive apheresis in patients with Crohn's disease: A multicenter retrospective pilot study.
Ueno, Nobuhiro; Saito, Seisuke; Sato, Masahiro; Sugiyama, Yuya; Kobayashi, Yu; Murakami, Yuki; Sugimura, Kohjiro; Sasaki, Takahiro; Sakatani, Aki; Takahashi, Keitaro; Tanaka, Kazuyuki; Serikawa, Shinya; Ando, Katsuyoshi; Kashima, Shin; Muto, Momotaro; Inaba, Yuhei; Moriichi, Kentaro; Tanabe, Hiroki; Okumura, Toshikatsu; Fujiya, Mikihiro.
Afiliación
  • Ueno N; Division of General Medicine, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan.
  • Saito S; Department of Gastroenterological Sciences, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Sato M; Furano Hospital, Furano, Hokkaido, Japan.
  • Sugiyama Y; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Kobayashi Y; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Murakami Y; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Sugimura K; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Sasaki T; Nakashibetsu Town Hospital, Nakashibetsu, Hokkaido, Japan.
  • Sakatani A; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Takahashi K; Department of Gastroenterological Sciences, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Tanaka K; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Serikawa S; Asahikawa Kosei General Hospital, Asahikawa, Hokkaido, Japan.
  • Ando K; Nayoro City General Hospital, Nayoro, Hokkaido, Japan.
  • Kashima S; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Muto M; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Inaba Y; Engaru Kosei General Hospital, Engaru, Hokkaido, Japan.
  • Moriichi K; Asahikawa City Hospital, Asahikawa, Hokkaido, Japan.
  • Tanabe H; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Okumura T; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
  • Fujiya M; Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Ther Apher Dial ; 28(3): 442-452, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38168492
ABSTRACT

INTRODUCTION:

A remission induction therapy of granulocyte and monocyte adsorptive apheresis (GMA) was given to patients with Crohn's disease (CD). However, establishing an appropriate treatment strategy for GMA in patients with CD remains unclear.

METHODS:

This study evaluated the clinical efficacy and subsequent clinical progression after GMA in patients with CD who underwent GMA in seven independent institutions in Japan from 2010 to 2023.

RESULTS:

Sixteen patients were enrolled. The overall remission and response rates were 25.0% and 68.8%, respectively. All patients responding to GMA received biologics that were continuously used and 36.4% of patients remained on the same biologics 52 weeks after GMA. Notably, all patients who continued the same biologics had previously experienced a loss of response to biologics.

CONCLUSION:

GMA may exhibit effectiveness even in cases with refractory CD. Moreover, it represents a potential novel therapeutic option for refractory CD with loss of response to biologics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eliminación de Componentes Sanguíneos / Monocitos / Enfermedad de Crohn / Granulocitos Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ther Apher Dial Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eliminación de Componentes Sanguíneos / Monocitos / Enfermedad de Crohn / Granulocitos Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Ther Apher Dial Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia