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The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity.
Kalkreuter, Edward; Kautsar, Satria A; Yang, Dong; Bader, Chantal D; Teijaro, Christiana N; Fluegel, Lucas L; Davis, Christina M; Simpson, Johnathon R; Lauterbach, Lukas; Steele, Andrew D; Gui, Chun; Meng, Song; Li, Gengnan; Viehrig, Konrad; Ye, Fei; Su, Ping; Kiefer, Alexander F; Nichols, Angela; Cepeda, Alexis J; Yan, Wei; Fan, Boyi; Jiang, Yanlong; Adhikari, Ajeeth; Zheng, Cheng-Jian; Schuster, Layla; Cowan, Tyler M; Smanski, Michael J; Chevrette, Marc G; de Carvalho, Luiz P S; Shen, Ben.
Afiliación
  • Kalkreuter E; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Kautsar SA; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Yang D; Current address: DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
  • Bader CD; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Teijaro CN; Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Fluegel LL; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Davis CM; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Simpson JR; Current address: Department of Discovery Chemistry, Bristol-Meyers Squibb, Princeton, NJ 08543.
  • Lauterbach L; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Steele AD; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, FL 33458.
  • Gui C; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Meng S; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, FL 33458.
  • Li G; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Viehrig K; Current address: Prepaire Labs, Pompano Beach, FL 33060.
  • Ye F; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Su P; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Kiefer AF; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Nichols A; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Cepeda AJ; Current address: State Key Laboratory of Drug Research & Natural Products Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China, Beijing, China 100049.
  • Yan W; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Fan B; Current address: Centivax Inc., South San Francisco, CA 94080.
  • Jiang Y; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Adhikari A; Current address: Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Portugal 4450-208.
  • Zheng CJ; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Schuster L; Current address: Department of Biological Chemistry & Molecular Pharmacology, Harvard University, Boston, MA 02115.
  • Cowan TM; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Smanski MJ; Current address: State Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China 100700.
  • Chevrette MG; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • de Carvalho LPS; Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL 33458.
  • Shen B; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, FL 33458.
bioRxiv ; 2024 May 02.
Article en En | MEDLINE | ID: mdl-38168313
ABSTRACT
Actinobacteria, the bacterial phylum most renowned for natural product discovery, has been established as a valuable source for drug discovery and biotechnology but is underrepresented within accessible genome and strain collections. Herein, we introduce the Natural Products Discovery Center (NPDC), featuring 122,449 strains assembled over eight decades, the genomes of the first 8490 NPDC strains (7142 Actinobacteria), and the online NPDC Portal making both strains and genomes publicly available. A comparative survey of RefSeq and NPDC Actinobacteria highlights the taxonomic and biosynthetic diversity within the NPDC collection, including three new genera, hundreds of new species, and ~7000 new gene cluster families. Selected examples demonstrate how the NPDC Portal's strain metadata, genomes, and biosynthetic gene clusters can be leveraged using genome mining approaches. Our findings underscore the ongoing significance of Actinobacteria in natural product discovery, and the NPDC serves as an unparalleled resource for both Actinobacteria strains and genomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos