Your browser doesn't support javascript.
loading
Autoimmune gastritis serological biomarkers in gastric cancer patients.
Krike, Petra; Appel, Meret Sophia; Shums, Zakera; Polaka, Inese; Kojalo, Ilona; Rudzite, Dace; Tolmanis, Ivars; Kirsners, Arnis; Bogdanova, Inga; Aleksandravica, Ilona; Norman, Gary L; Leja, Marcis.
Afiliación
  • Krike P; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Appel MS; Pauls Stradins Clinical University Hospital, Riga, Latvia.
  • Shums Z; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Polaka I; Headquarters & Technology Center Autoimmunity, Werfen, San Diego, California, USA.
  • Kojalo I; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Rudzite D; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Tolmanis I; Riga East University Hospital.
  • Kirsners A; Digestive Diseases Centre GASTRO.
  • Bogdanova I; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Aleksandravica I; Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia.
  • Norman GL; Riga East University Hospital.
  • Leja M; Academic Histology Laboratory, Riga, Latvia.
Eur J Cancer Prev ; 33(1): 29-36, 2024 Jan 01.
Article en En | MEDLINE | ID: mdl-38167662
ABSTRACT
The role of autoimmunity in the pathogenesis of gastric cancer remains controversial. We studied antiparietal cell antibody (anti-PCA) and anti-intrinsic factor antibody (anti-IFA) levels and their associations with pepsinogen I/pepsinogen II levels in patients with gastric adenocarcinoma compared to a control group with mild or no atrophy of the stomach mucosa. Plasma levels of anti-PCA and anti-IFA were measured by ELISA (Inova Diagnostics Inc, San Diego, California, USA). The cutoff value for anti-PCA and anti-IFA positivity was ≥25 units. Altogether 214 patients (126 men, 88 women, median age 64.46, range 35-86) with confirmed gastric adenocarcinoma and 214 control cases paired for age and sex were included in the study. Positive anti-PCA was present in 22 (10.3%) gastric cancer patients and controls (P ≥ 0.999); positive anti-IFA in 6 (2.8%) and 4 (1.9.%), P < 0.232, respectively. We did not find significant differences in anti-PCA and anti-IFA positivity between gastric cancer patients and the control group; further investigation is required to better understand the potential involvement of autoimmune gastritis in the development of gastric cancer.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Helicobacter pylori / Infecciones por Helicobacter / Gastritis / Gastritis Atrófica Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Helicobacter pylori / Infecciones por Helicobacter / Gastritis / Gastritis Atrófica Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido