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Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications.
Engström, Gunnar; Lampa, Erik; Dekkers, Koen; Lin, Yi-Ting; Ahlm, Kristin; Ahlström, Håkan; Alfredsson, Joakim; Bergström, Göran; Blomberg, Anders; Brandberg, John; Caidahl, Kenneth; Cederlund, Kerstin; Duvernoy, Olov; Engvall, Jan E; Eriksson, Maria J; Fall, Tove; Gigante, Bruna; Gummesson, Anders; Hagström, Emil; Hamrefors, Viktor; Hedner, Jan; Janzon, Magnus; Jernberg, Tomas; Johnson, Linda; Lind, Lars; Lindberg, Eva; Mannila, Maria; Nilsson, Ulf; Persson, Anders; Persson, Hans Lennart; Persson, Margaretha; Ramnemark, Anna; Rosengren, Annika; Schmidt, Caroline; Skoglund Larsson, Linn; Sköld, C Magnus; Swahn, Eva; Söderberg, Stefan; Torén, Kjell; Waldenström, Anders; Wollmer, Per; Zaigham, Suneela; Östgren, Carl Johan; Sundström, Johan.
Afiliación
  • Engström G; Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden. Gunnar.Engstrom@med.lu.se.
  • Lampa E; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Dekkers K; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Lin YT; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Ahlm K; Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Huddinge, Sweden.
  • Ahlström H; Department of Family Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.
  • Alfredsson J; Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
  • Bergström G; Department of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden.
  • Blomberg A; BFC, Uppsala University Hospital, Uppsala, Sweden.
  • Brandberg J; Antaros Medical AB, Mölndal, Sweden.
  • Caidahl K; Department of Cardiology, Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.
  • Cederlund K; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Duvernoy O; Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Engvall JE; Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
  • Eriksson MJ; Department of Radiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Fall T; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Gigante B; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
  • Gummesson A; Department of Clinical Physiology, Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg, Sweden.
  • Hagström E; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Hamrefors V; Department of Surgical Sciences, Section of Radiology, Uppsala University, Uppsala, Sweden.
  • Hedner J; CMIV, Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
  • Janzon M; Department of Clinical Physiology; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • Jernberg T; Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.
  • Johnson L; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  • Lind L; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Lindberg E; Division of Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
  • Mannila M; Department of Clinical Science, Danderyd University Hospital, Stockholm, Sweden.
  • Nilsson U; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Persson A; Department of Clinical Genetics and Genomics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Persson HL; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
  • Persson M; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
  • Ramnemark A; Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
  • Rosengren A; Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
  • Schmidt C; Pulmonary Department, Sleep Disorders Center, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Skoglund Larsson L; Center of Sleep and Wake Disorders, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden.
  • Sköld CM; Department of Cardiology, Department of Health, Medicine and Caring Sciences, Unit of Cardiovascular Sciences, Linköping University, Linköping, Sweden.
  • Swahn E; Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
  • Söderberg S; Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
  • Torén K; Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
  • Waldenström A; Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
  • Wollmer P; Heart and Vascular Theme, Department of Cardiology, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
  • Zaigham S; Department of Public Health and Clinical Medicine, Section of Medicine, Umeå University, Umeå, Sweden.
  • Östgren CJ; CMIV, Centre of Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
  • Sundström J; Department of Radiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Eur J Epidemiol ; 39(1): 35-49, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38165527
ABSTRACT
Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Enfermedades de las Arterias Carótidas / Enfisema / Aterosclerosis Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Enfermedades de las Arterias Carótidas / Enfisema / Aterosclerosis Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Eur J Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos