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Gordon Holmes Syndrome Model Mice Exhibit Alterations in Microglia, Age, and Sex-Specific Disruptions in Cognitive and Proprioceptive Function.
George, Arlene J; Wei, Wei; Pyaram, Dhanya N; Gomez, Morgan; Shree, Nitheyaa; Kadirvelu, Jayashree; Lail, Hannah; Wanders, Desiree; Murphy, Anne Z; Mabb, Angela M.
Afiliación
  • George AJ; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Wei W; Center for Behavioral Neuroscience, Georgia State University, Atlanta 30303, Georgia.
  • Pyaram DN; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Gomez M; Center for Behavioral Neuroscience, Georgia State University, Atlanta 30303, Georgia.
  • Shree N; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Kadirvelu J; Center for Behavioral Neuroscience, Georgia State University, Atlanta 30303, Georgia.
  • Lail H; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Wanders D; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Murphy AZ; Neuroscience Institute, Georgia State University, Atlanta 30302, Georgia.
  • Mabb AM; Department of Nutrition, Georgia State University, Atlanta 30303, Georgia.
eNeuro ; 11(1)2024 Jan.
Article en En | MEDLINE | ID: mdl-38164552
ABSTRACT
Gordon Holmes syndrome (GHS) is a neurological disorder associated with neuroendocrine, cognitive, and motor impairments with corresponding neurodegeneration. Mutations in the E3 ubiquitin ligase RNF216 are strongly linked to GHS. Previous studies show that deletion of Rnf216 in mice led to sex-specific neuroendocrine dysfunction due to disruptions in the hypothalamic-pituitary-gonadal axis. To address RNF216 action in cognitive and motor functions, we tested Rnf216 knock-out (KO) mice in a battery of motor and learning tasks for a duration of 1 year. Although male and female KO mice did not demonstrate prominent motor phenotypes, KO females displayed abnormal limb clasping. KO mice also showed age-dependent strategy and associative learning impairments with sex-dependent alterations of microglia in the hippocampus and cortex. Additionally, KO males but not females had more negative resting membrane potentials in the CA1 hippocampus without any changes in miniature excitatory postsynaptic current (mEPSC) frequencies or amplitudes. Our findings show that constitutive deletion of Rnf216 alters microglia and neuronal excitability, which may provide insights into the etiology of sex-specific impairments in GHS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia Cerebelosa / Hormona Liberadora de Gonadotropina / Microglía / Hipogonadismo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ataxia Cerebelosa / Hormona Liberadora de Gonadotropina / Microglía / Hipogonadismo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos