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Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.
Gopal, Radha; Tutuncuoglu, Egemen; Bakalov, Veli; Wasserloos, Karla; Li, HuiHua; Lemley, David; DeVito, Louis J; Constantinesco, Nicholas J; Reed, Douglas S; McHugh, Kevin J; Chinnappan, Baskaran; Andreas, Alexis R; Maloy, Abigail; Bain, Daniel; Alcorn, John F; Pitt, Bruce R; Kaynar, Ata Murat.
Afiliación
  • Gopal R; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Tutuncuoglu E; The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Bakalov V; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Wasserloos K; The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Li H; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Lemley D; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • DeVito LJ; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Constantinesco NJ; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Reed DS; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • McHugh KJ; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Chinnappan B; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Andreas AR; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Maloy A; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Bain D; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Alcorn JF; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Pitt BR; Department of Geology and Planetary Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Kaynar AM; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Physiol Rep ; 12(1): e15902, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38163670
ABSTRACT
Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide the first preclinical evidence demonstrating that although diet-induced acute zinc deficiency (Zn-D ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin-resistant staph aureus (MRSA), Zn-D mice were sensitive to the injurious effects of superinfection of H1N1 with MRSA. Although the mechanism underlying the sensitivity of ZnD mice to combined H1N1/MRSA infection is unclear, it was noteworthy that this combination exacerbated lung injury as shown by lung epithelial injury markers (increased BAL protein) and decreased genes related to epithelial integrity in Zn-D mice (surfactant protein C and secretoglobins family 1A member 1). As bacterial pneumonia accounts for 25%-50% of morbidity and mortality from influenza A infection, zinc deficiency may be an important pathology component of respiratory tract infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Bacteriana / Desnutrición / Subtipo H1N1 del Virus de la Influenza A / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Diagnostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Bacteriana / Desnutrición / Subtipo H1N1 del Virus de la Influenza A / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Diagnostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Physiol Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos