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Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions. / 5-羟色胺3受体对焦虑反应的调节作用.
DU, Yinan; Li, Zhiwei; Zhao, Yukui; Han, Jing; Hu, Weiping; Liu, Zhiqiang.
Afiliación
  • DU Y; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
  • Li Z; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
  • Zhao Y; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
  • Han J; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China.
  • Hu W; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China. liuzhiqiang@snnu.edu.cn, weipinghu@163.com.
  • Liu Z; MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an 710062, China. liuzhiqiang@snnu.edu.cn.
J Zhejiang Univ Sci B ; 25(1): 23-37, 2024 Jan 15.
Article en En, Zh | MEDLINE | ID: mdl-38163664
ABSTRACT
5-Hydroxytryptamine (5-HT) type 3 receptor (5-HT3R) is the only type of ligand-gated ion channel in the 5-HT receptor family. Through the high permeability of Na+, K+, and Ca2+ and activation of subsequent voltage-gated calcium channels (VGCCs), 5-HT3R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system (CNS). 5-HT3Rs are widely expressed in the medial prefrontal cortex (mPFC), amygdala (AMYG), hippocampus (HIP), periaqueductal gray (PAG), and other brain regions closely associated with anxiety reactions. They have a bidirectional regulatory effect on anxiety reactions by acting on different types of cells in different brain regions. 5-HT3Rs mediate the activation of the cholecystokinin (CCK) system in the AMYG, and the γ|-aminobutyric acid (GABA) "disinhibition" mechanism in the prelimbic area of the mPFC promotes anxiety by the activation of GABAergic intermediate inhibitory neurons (IINs). In contrast, a 5-HT3R-induced GABA "disinhibition" mechanism in the infralimbic area of the mPFC and the ventral HIP produces anxiolytic effects. 5-HT2R-mediated regulation of anxiety reactions are also activated by 5-HT3R-activated 5-HT release in the HIP and PAG. This provides a theoretical basis for the treatment of anxiety disorders or the production of anxiolytic drugs by targeting 5-HT3Rs. However, given the circuit specific modulation of 5-HT3Rs on emotion, systemic use of 5-HT3R agonism or antagonism alone seems unlikely to remedy anxiety, which deeply hinders the current clinical application of 5-HT3R drugs. Therefore, the exploitation of circuit targeting methods or a combined drug strategy might be a useful developmental approach in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Receptores de Serotonina 5-HT3 Idioma: En / Zh Revista: J Zhejiang Univ Sci B Asunto de la revista: BIOLOGIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Receptores de Serotonina 5-HT3 Idioma: En / Zh Revista: J Zhejiang Univ Sci B Asunto de la revista: BIOLOGIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China