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Circulating mitochondrial long non-coding 7S RNA in primary health care patients with depression/anxiety.
Wang, Xiao; Memon, Ashfaque A; Hedelius, Anna; Grundberg, Anton; Sundquist, Jan; Sundquist, Kristina.
Afiliación
  • Wang X; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden. Electronic address: xiao.wang@med.lu.se.
  • Memon AA; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden.
  • Hedelius A; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden.
  • Grundberg A; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden.
  • Sundquist J; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden; Department of Family Medicine and Community Health, Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai, New York, USA; Center for Community-based Healthcare Research an
  • Sundquist K; Center for Primary Health Care Research, Lund University/Region Skåne, Malmö 20502, Sweden; Department of Family Medicine and Community Health, Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai, New York, USA; Center for Community-based Healthcare Research an
J Affect Disord ; 349: 101-106, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38163568
ABSTRACT

BACKGROUND:

The significant role of long non-coding 7S RNA in controlling mitochondrial transcription highlights its importance in mitochondrial function. Considering the suggested connection between mitochondrial dysfunction and the onset of mental disorders, this study aimed to explore the potential involvement of 7S RNA in the context of depression/anxiety.

RESULTS:

A total of 181 patients in primary health care (age 20-64 years) with depression/anxiety and 59 healthy controls were included in the study. 7S RNA was measured using quantitative real-time PCR in plasma samples collected before (baseline) and after 8 weeks of treatment (mindfulness or cognitive-based behavioral therapy). Upon adjustment for age and sex, the baseline plasma levels of 7S RNA were significantly higher in patients than in healthy controls (p < 0.001). Notably, post-treatment, there was a significant reduction in 7S RNA levels (p = 0.03). These changes in 7S RNA were related to the treatment response, as indicated by HADS-D (Hospital Anxiety and Depression Scale) scores (ß = -0.04, p = 0.04), even after accounting for baseline scores and other cofounders.

CONCLUSION:

The findings of this study indicate an association between plasma 7S RNA levels and depression/anxiety, as well as treatment response. While further confirmatory analyses are necessary, plasma 7S RNA holds promise as a potential predictive biomarker for both depression/anxiety and the treatment response within these disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Partícula de Reconocimiento de Señal / ARN Citoplasmático Pequeño / Depresión Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Partícula de Reconocimiento de Señal / ARN Citoplasmático Pequeño / Depresión Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos