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Improvement of dyspeptic symptoms after Helicobacter pylori eradication therapy in Japanese patients.
Iwata, Eri; Sugimoto, Mitsushige; Murata, Masaki; Morino, Yuko; Akimoto, Yoshika; Hamada, Mariko; Niikura, Ryota; Nagata, Naoyoshi; Kawai, Takashi.
Afiliación
  • Iwata E; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Sugimoto M; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Murata M; Department of Gastroenterology National Hospital Organization Kyoto Medical Center Kyoto Japan.
  • Morino Y; Tokyo University of Pharmacy and Life Sciences Tokyo Japan.
  • Akimoto Y; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Hamada M; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Niikura R; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Nagata N; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
  • Kawai T; Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan.
JGH Open ; 7(12): 855-862, 2023 Dec.
Article en En | MEDLINE | ID: mdl-38162864
ABSTRACT
Background and

Aim:

Helicobacter pylori eradication therapy effectively improves the abdominal symptoms and bowel habits of patients. Patients in whom dyspepsia is under control by 6 to 12 months after successful H. pylori eradication are defined as having H. pylori-associated dyspepsia, and patients with dyspepsia that is refractory to successful eradication are defined as having functional dyspepsia. Here, we aimed to investigate the association between H. pylori eradication and improvement of dyspepsia in the short and long term after eradication therapy.

Methods:

Dyspeptic symptoms before treatment and at 2 and 12 months after eradication were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS) in 282 H. pylori-positive Japanese patients who underwent eradication therapy.

Results:

Of the Japanese H. pylori-positive patients, 48.2% (136/282) had upper abdominal symptoms. Eradication improved dyspepsia in 34.5% (47/136) of the patients at 2 months post eradication, which continued to be under control up to 12 months. A significant decrease at 2 and 12 months after eradication, compared with before eradication, was observed in total GSRS (from 25.7 ± 10.4 [before eradication, n = 249] to 23.3 ± 7.2 [after 2 months, n = 249] and 24.8 ± 7.8 [after 12 months, n = 81]; P = 0.014 and 0.321, respectively), gastric pain score (from 4.1 ± 1.9 to 3.7 ± 1.3 and 3.7 ± 1.2; P = 0.025 and 0.047), and constipation score (from 5.9 ± 3.1 to 5.2 ± 2.3 and 5.9 ± 3.0; P < 0.021 and 0.862).

Conclusion:

H. pylori-positive dyspepsia patients should be recommended to undergo H. pylori eradication to alleviate dyspepsia-associated symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: JGH Open Año: 2023 Tipo del documento: Article Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: JGH Open Año: 2023 Tipo del documento: Article Pais de publicación: Australia