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Primary biliary cirrhosis and osteoporosis: a bidirectional two-sample Mendelian randomization study.
Zhao, Diqian; Li, Guobi; Bai, Wenzhe; Teng, Jiawen; Yan, Bing; Han, Cong.
Afiliación
  • Zhao D; The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Li G; Department of Pediatric Orthopedics, Affiliated Hospital of Shandong Traditional Chinese Medicine University, Jinan, China.
  • Bai W; The First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Teng J; Department of Micro Orthopedics, Affiliated Hospital of Shandong Traditional Chinese Medicine University, Jinan, China.
  • Yan B; Department of Joint Oncology Orthopedics, Affiliated Hospital of Shandong Traditional Chinese Medicine University, Jinan, China.
  • Han C; Nephropathy Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Immunol ; 14: 1269069, 2023.
Article en En | MEDLINE | ID: mdl-38162659
ABSTRACT

Background:

Observational studies have identified a heightened risk of osteoporosis and fractures in patients with primary biliary cholangitis (PBC). However, conclusive evidence establishing a causal relationship between the two, and a clear mechanism explaining this association, remains elusive.

Methods:

We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between PBC and osteoporosis. This analysis utilized five MR

methods:

inverse-variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode. Sensitivity analyses were performed, employing various models and testing methods, to assess the impact of heterogeneity and pleiotropy on the results and to confirm their robustness.

Results:

A causal relationship between PBC and osteoporosis risk was established through IVW analysis (OR 1.049, 95%CI 1.017-1.082, P=0.002). Three other MR analyses corroborated these findings. Conversely, osteoporosis was not found to causally affect PBC risk, as evidenced by IVW analysis (OR 0.941, 95%CI 0.783-1.129, P=0.511). Across all MR analyses, no heterogeneity or horizontal pleiotropy was detected among the instrumental variables (IVs). Furthermore, the leave-one-out analysis indicated that no single SNP disproportionately influenced the results, affirming the reliability of the bidirectional MR findings.

Conclusion:

This study establishes a positive causal relationship between PBC and the risk of osteoporosis, while no definitive causal link was found from osteoporosis to PBC. These findings offer new insights and guidance for managing bone health in PBC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Fracturas Óseas / Cirrosis Hepática Biliar Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Fracturas Óseas / Cirrosis Hepática Biliar Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza