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Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.
Burzynska, Agnieszka Z; Anderson, Charles; Arciniegas, David B; Calhoun, Vince; Choi, In-Young; Colmenares, Andrea Mendez; Hiner, Grace; Kramer, Arthur F; Li, Kaigang; Lee, Jongho; Lee, Phil; Oh, Se-Hong; Umland, Samantha; Thomas, Michael L.
Afiliación
  • Burzynska AZ; The BRAiN lab, Department of Human Development and Family Studies/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, USA.
  • Anderson C; Department of Computer Science, Colorado State University, Fort Collins, CO, USA.
  • Arciniegas DB; Marcus Institute for Brain Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Calhoun V; Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Choi IY; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.
  • Colmenares AM; Department of Neurology, Department of Radiology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA.
  • Hiner G; The BRAiN lab, Department of Human Development and Family Studies/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, USA.
  • Kramer AF; The BRAiN lab, Department of Human Development and Family Studies/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, USA.
  • Li K; Beckman Institute for Advanced Science and Technology at the University of Illinois, IL, USA.
  • Lee J; Center for Cognitive & Brain Health, Northeastern University, Boston, MA, USA.
  • Lee P; Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA.
  • Oh SH; Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
  • Umland S; Department of Radiology, Hoglund Biomedical Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA.
  • Thomas ML; Division of Biomedical Engineering, Hankuk University of Foreign Studies, Gyeonggi-do, Republic of Korea.
Cereb Circ Cogn Behav ; 5: 100180, 2023.
Article en En | MEDLINE | ID: mdl-38162292
ABSTRACT
Metabolic syndrome (MetS) is a cluster of conditions that affects ∼25% of the global population, including excess adiposity, hyperglycemia, dyslipidemia, and elevated blood pressure. MetS is one of major risk factors not only for chronic diseases, but also for dementia and cognitive dysfunction, although the underlying mechanisms remain poorly understood. White matter is of particular interest in the context of MetS due to the metabolic vulnerability of myelin maintenance, and the accumulating evidence for the importance of the white matter in the pathophysiology of dementia. Therefore, we investigated the associations of MetS risk score and adiposity (combined body mass index and waist circumference) with myelin water fraction measured with myelin water imaging. In 90 cognitively and neurologically healthy adults (20-79 years), we found that both high MetS risk score and adiposity were correlated with lower myelin water fraction in late-myelinating prefrontal and associative fibers, controlling for age, sex, race, ethnicity, education and income. Our findings call for randomized clinical trials to establish causality between MetS, adiposity, and myelin content, and to explore the potential of weight loss and visceral adiposity reduction as means to support maintenance of myelin integrity throughout adulthood, which could open new avenues for prevention or treatment of cognitive decline and dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Idioma: En Revista: Cereb Circ Cogn Behav Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Idioma: En Revista: Cereb Circ Cogn Behav Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos