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Characteristics and incidence of cardiac events across spectrum of age in cardiac sarcoidosis.
Nabeta, Takeru; Matsumoto, Shingo; Ishii, Shunsuke; Eda, Yuko; Yazaki, Mayu; Fujita, Teppei; Iida, Yuichiro; Ikeda, Yuki; Kitai, Takeshi; Naruse, Yoshihisa; Taniguchi, Tatsunori; Yoshioka, Kenji; Tanaka, Hidekazu; Okumura, Takahiro; Baba, Yuichi; Matsue, Yuya; Ako, Junya.
Afiliación
  • Nabeta T; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Matsumoto S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Ishii S; Division of Cardiovascular Medicine, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
  • Eda Y; British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
  • Yazaki M; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Fujita T; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Iida Y; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Ikeda Y; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Kitai T; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Naruse Y; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
  • Taniguchi T; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
  • Yoshioka K; Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Tanaka H; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Okumura T; Department of Cardiology, Kameda Medical Center, Chiba, Japan.
  • Baba Y; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Matsue Y; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ako J; Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University, Nankoku, Japan.
Int J Cardiol Heart Vasc ; 50: 101321, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38161782
ABSTRACT

Background:

Clinical characteristics and the risk of cardiovascular events in patients with cardiac sarcoidosis (CS) according to the age of initial diagnosis are unclear.

Methods:

This study is a sub-analysis of the ILLUMINATE-CS registry, which is a retrospective, multicenter registry that enrolled patients with CS between 2001 and 2017. Patients were divided into three groups according to the tertile of age at the time of initial diagnosis of CS. The study compared the clinical background at the time of CS diagnosis and the incidence rate of cardiac events across age categories.

Results:

A total of 511 patients were analyzed in this study. In baseline, older patients were more likely to be female. History of hypertension, heart failure admission, and atrioventricular block were more common in patients with older age. There was no significant difference in the history of ventricular arrhythmias and left ventricular ejection fraction among all age groups. During a median follow-up period of 3.2 [IQR 1.7-4.2] years, 35 deaths, 56 heart failure hospitalization, and 98 fatal ventricular arrhythmias was observed. The incidence rate of all-cause death and heart failure hospitalization was significantly higher in patients with older age (p < 0.001), while there was no significant difference in the incidence rate of ventricular arrhythmia among age groups (p = 0.74).

Conclusions:

In patients with CS, the risk of all-cause death and heart failure hospitalization was higher in older patients compared with other age groups; however, the risk of ventricular arrhythmia was comparable across all age groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Incidence_studies / Risk_factors_studies Idioma: En Revista: Int J Cardiol Heart Vasc Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Incidence_studies / Risk_factors_studies Idioma: En Revista: Int J Cardiol Heart Vasc Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda