Your browser doesn't support javascript.
loading
A comprehensive review of HVS-I mitochondrial DNA variation of 19 Iranian populations.
Amjadi, Motahareh; Hayatmehr, Zahra; Egyed, Balázs; Tavallaei, Mahmood; Szécsényi-Nagy, Anna.
Afiliación
  • Amjadi M; Department of Genetics, ELTE Doctoral School of Biology, Eötvös Loránd University, Budapest, Hungary.
  • Hayatmehr Z; HUN-REN Research Centre for the Humanities, Institute of Archaeogenomics, Budapest, Hungary.
  • Egyed B; Faculty of Management and Financial Science, Department of Management, Khatam University, Tehran, Iran.
  • Tavallaei M; Department of Genetics, ELTE Eötvös Loránd University, Budapest, Hungary.
  • Szécsényi-Nagy A; Kawsar Human Genetic Research Center, Tehran, Iran.
Ann Hum Genet ; 88(3): 259-277, 2024 May.
Article en En | MEDLINE | ID: mdl-38161274
ABSTRACT
Iran is located along the Central Asian corridor, a natural artery that has served as a cross-continental route since the first anatomically modern human populations migrated out of Africa. We compiled and reanalyzed the HVS-I (hypervariable segment-I) of 3840 mitochondrial DNA (mtDNA) sequences from 19 Iranian populations and from 26 groups from adjacent countries to give a comprehensive review of the maternal genetic variation and investigate the impact of historical events and cultural factors on the maternal genetic structure of modern Iranians. We conclude that Iranians have a high level of genetic diversity. Thirty-six haplogroups were observed in Iran's populations, and most of them belong to widespread West-Eurasian haplogroups, such as H, HV, J, N, T, and U. In contrast, the predominant haplogroups observed in most of the adjacent countries studied here are H, M, D, R, U, and C haplogroups. Using principal component analysis, clustering, and genetic distance-based calculations, we estimated moderate genetic relationships between Iranian and other Eurasian groups. Further, analyses of molecular variance and comparing geographic and genetic structures indicate that mtDNA HVS-I sequence diversity does not exhibit any sharp geographic structure in the country. Barring a few from some culturally distinct and naturally separated minorities, most Iranian populations have a homogenous maternal genetic structure.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genética de Población / Pueblos de Medio Oriente Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Ann Hum Genet Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genética de Población / Pueblos de Medio Oriente Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Ann Hum Genet Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Reino Unido