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Donor blood cultures and outcomes after lung transplantation: a single-center report.
Hashim, Mahmoud; Saleh, Rana Ahmed; Abdulqawi, Rayid; Albachir, Chams Alkhalaf; Aldakhil, Haifa; AlKattan, Khaled Manae; Almaghrabi, Reem Saad; Hamad, Alaa; Saleh, Waleed; Al-Mutairy, Eid Abdullah.
Afiliación
  • Hashim M; Lung Health Centre Department, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Saleh RA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Abdulqawi R; Lung Health Centre Department, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Albachir CA; Lung Health Centre Department, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Aldakhil H; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • AlKattan KM; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Almaghrabi RS; Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Hamad A; Lung Health Centre Department, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Saleh W; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Al-Mutairy EA; Section of Transplant Infectious Diseases, Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Transpl Infect Dis ; 26(2): e14224, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38160331
ABSTRACT

BACKGROUND:

Transplanting lungs from donors with positive blood cultures has not been shown to adversely affect survival. There is limited evidence for potential effects on other outcomes, such as hospital course, graft function, and transmission of infection.

METHODS:

This retrospective cohort study included adult patients who underwent lung-only transplantation for the first time between March 2010 and December 2022. Outcomes of patients whose donors had positive blood cultures within 72 h of transplant were compared to patients whose donors had negative blood cultures.

RESULTS:

Twenty-five (10.8%) of 232 donors had positive blood cultures, including a single, unexpected case with candidemia. The most commonly isolated bacteria were Enterobacter cloacae (n = 5), Klebsiella pneumoniae (n = 5), Acinetobacter baumannii (n = 3), Pseudomonas aeruginosa (n = 3), and Staphylococcus aureus (n = 3). Eleven donors had identical bacteria in their respiratory cultures. All patients who were transplanted from donors with positive blood cultures survived beyond 90 days. Positive donor blood cultures were not associated with longer hospital stay, in-hospital complications, acute cellular rejection, or the achievement of 80% predicted forced expiratory volume in the first second. Probable transmission of donor bacteremia occurred in only two cases (both with S. aureus). These two donors had positive respiratory cultures with the same organism.

CONCLUSION:

The study did not find an increased risk of adverse events when transplanting lungs from donors with positive blood cultures. Allograft cultures may be more predictive of the risk of transmitting infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Trasplante de Pulmón Límite: Adult / Humans Idioma: En Revista: Transpl Infect Dis Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Trasplante de Pulmón Límite: Adult / Humans Idioma: En Revista: Transpl Infect Dis Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Dinamarca