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Genetic Risk of Rheumatoid Arthritis: A Case Control Study.
Ahmad, Hosam M; Zaki, Zaki M; Mohamed, Asmaa S; Ahmed, Amr E.
Afiliación
  • Ahmad HM; Biotechnology and Life Sciences Department, Faculty of Post Graduate Studies for Advanced Sciences, Beni-Suef university, Beni-Suef, Egypt.
  • Zaki ZM; Internal Medicine and Biomedical Chemistry Departments, Egypt Ministry of Health and Population, Minia, 61511, Egypt.
  • Mohamed AS; Clinical Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt.
  • Ahmed AE; Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt. Asmaa.Mohamed@pharm.psu.edu.eg.
Biochem Genet ; 62(5): 3624-3641, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38160213
ABSTRACT
Vitamin D effects are mediated by vitamin D receptors (VDRs), which are influenced by various genetic polymorphisms, including ApaI and BsmI. These polymorphisms have been linked to several diseases, including rheumatoid arthritis (RA). This study aimed to compare the frequency and association of VDR ApaI and BsmI gene polymorphisms, serum 25-hydroxy vitamin D (25-(OH)-D) levels, and calcium (Ca) levels between a RA group and a matched healthy control group. In one hundred RA patients and fifty healthy controls, the genotypes of the VDR ApaI and BsmI gene polymorphisms were analyzed using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLP). Both Serum 25-(OH)-D level and calcium level were measured in the two groups. There was no significant difference between the cases and controls regarding the VDR ApaI gene polymorphism (p = 0.89). A significant difference was observed between the cases and controls in terms of the VDR BsmI gene polymorphism (p = < 0.001). The serum levels of 25-(OH)-D and calcium were significantly lower in the RA group compared to the control group (p = 0.04 and < 0.001 respectively). Significantly higher serum vitamin D levels were associated with the aa genotype (p = 0.007). Significantly increased calcium levels were associated with the AA genotype (p = 0.02). No significant difference was found among BsmI polymorphisms regarding vitamin D and Ca levels (p = 0.25 and 0.87 respectively). Vitamin D receptor gene BsmI polymorphism but not ApaI polymorphism could be a marker of RA susceptibility. Vitamin D and Ca levels are negatively affected by RA. Vitamin D receptor gene ApaI polymorphism contributes to vitamin D and Ca levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Vitamina D / Receptores de Calcitriol / Predisposición Genética a la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Genet Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Vitamina D / Receptores de Calcitriol / Predisposición Genética a la Enfermedad Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Genet Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos